Cover Picture : The “cortical signature” of regional thinning in limbic and heteromodal association areas begins to emerge in asymptomatic amyloid- positive individuals (top), evolves in very mildly demented individuals (middle), and is reliably detectable in patients with mild Alzheimer's dementia (bottom). Advanced computational morphometric MRI technology enables the nearly fully-automated measurement of cortical thickness across the brain and allows for detection of regionally specific thinning, which-in populations such as this-is thought to be associated with neurodegenerative pathology. See Dickerson et al. 2009. The cortical signature of Alzheimer's disease: Regionally-specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex 19(3): 497–510.
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