Mosaic summarizing a multidisciplinary approach to study single neurons combining: molecular profiling, morphological identification, electrophysiological characterization, biostatistics and mathematical modeling. Background infrared image of rat somatosensory cortex superimposed with 3-D reconstructions of three interneurons and one pyramidal cell. From top to bottom: Infrared image of a neuron during patch clamp recordings. Two agarose gels showing PCR amplified products from a single neuron. Correlation matrix of similarity coefficients where each index represents the similarity of the entire gene expression profile of each cell (for the 29 studied genes) with each one of the other studied cells. Correlation matrix of similarity coefficients where each index represents the similarity of the electrical properties of each cell with each one of the other studied cells. Voltage response by a Stuttering neuron to a square current pulse injection. See Toledo-Rodriguez et al., pp. 1310-1327.
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