Cover Picture: Diffusible factors direct neuronal migration. The septum (left) and the subventricular zone (SVZ; center) were dissected from rat brain at postnatal day 8. These two explants were embedded in collagen gel 200 µm apart and cultured for 24 h. The fixed tissues were immunostained for class III ß-tubulin (green) and nuclear-stained for propidium iodide (red). Many young neurons migrate out from the SVZ; however, the neurons in proximity to the septal explant change their direction of movement, leading to the asymmetrical distribution of migrating neurons. This shows that the septum secretes diffusible molecule(s) acting repulsively on the migration of SVZ neurons. See Hamasaki et al., pp. 474–484.
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