Skip Navigation



Cerebral Cortex Advance Access published online on April 22, 2009
Cerebral Cortex, doi:10.1093/cercor/bhp045
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Data
Right arrow All Versions of this Article:
19/suppl_1/i96    most recent
bhp045v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Long, J. E.
Right arrow Articles by Rubenstein, J. L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Long, J. E.
Right arrow Articles by Rubenstein, J. L. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Dlx1&2 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping Pathways

Jason E. Long1,2, Inma Cobos1,3, Greg B. Potter1 and John L. R. Rubenstein1

1 Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, CA 94158-2324, USA

Address correspondence to John L. R. Rubenstein, Center for Neurobiology and Psychiatry, Department of Psychiatry, Rock Hall, Room RH 284C, UCSF MC 2611, 1550 4th Street, University of California at San Francisco, San Francisco, CA 94158-2324, USA. Email: john.rubenstein{at}ucsf.edu.

Here we define the expression of ~100 transcription factors (TFs) in progenitors and neurons of the developing mouse medial and caudal ganglionic eminences, anlage of the basal ganglia and pallial interneurons. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dlx homeodomain genes, which are essential for differentiation of most {gamma}-aminobutyric acidergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 basic helix-loop-helix (b-HLH) TF. These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons.

Key Words: CGE • Dlx • Mash • MGE • transcription factor

2 Current address: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA

3 Current address: Department of Cell Biology, University of Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.