Cerebral Cortex Advance Access published online on April 10, 2009
Cerebral Cortex, doi:10.1093/cercor/bhp042
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Structural Basis for Self-Renewal of Neural Progenitors in Cortical Neurogenesis
1 Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan
Address correspondence to email: fumio{at}cdb.riken.jp.
In mammalian brain development, neuroepithelial cells act as progenitors that produce self-renewing and differentiating cells. Recent technical advances in live imaging and gene manipulation now enable us to investigate how neural progenitors generate the 2 different types of cells with unprecedented accuracy and resolution, shedding new light on the roles of epithelial structure in cell fate decisions and also on the plasticity of neurogenesis.
Key Words: asymmetric division neural progenitor neuroepithelial cell self-renewal spindle orientation
2 Current address: Laboratory for Animal Resource and Genetic Engineering, RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan