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Cerebral Cortex Advance Access published online on April 14, 2009
Cerebral Cortex, doi:10.1093/cercor/bhp041
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© 2009 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

The Role of Robo3 in the Development of Cortical Interneurons

Melissa Barber1, Thomas Di Meglio2,3, William D. Andrews1, Luis R. Hernández-Miranda1, Fujio Murakami4, Alain Chédotal2,3 and John G. Parnavelas1

1 Department of Cell and Developmental Biology, University College London, London, UK, 2 Institute of Vision, 3 Université Pierre et Marie Curie-Paris 6, INSERM 592, Paris 75012, France, 4 Osaka University, Osaka, Japan

Address correspondence to Professor John G. Parnavelas, Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Email: j.parnavelas{at}ucl.ac.uk.

A number of studies in recent years have shown that members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons. Here, we investigated the expression and function of Robo3 in the developing cortex. We found that this receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal–Retzius cells and interneurons. Analysis of Robo3 mutant mice at early (embryonic day [E] 13.5) and late (E18.5) stages of corticogenesis revealed no significant change in the number of interneurons, but a change in their morphology at E13.5. However, preliminary analysis on a small number of mice that lacked all 3 Robo receptors indicated a marked reduction in the number of cortical interneurons, but only a limited effect on their morphology. These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons.

Key Words: interneuron • morphology • Robo


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