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Cerebral Cortex Advance Access published online on May 13, 2008
Cerebral Cortex, doi:10.1093/cercor/bhn069
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Enhanced Modulation of Neuronal Activity during Antisaccades in the Primate Globus Pallidus

Atsushi Yoshida1 and Masaki Tanaka1,2

1 Department of Physiology, Hokkaido University School of Medicine, North 15, West 7, Sapporo 060-8638, Japan, 2 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan

Address correspondence to email: masaki{at}med.hokudai.ac.jp

The antisaccade task has been widely used to investigate the neural mechanisms underlying volitional movement control. In this task, subjects suppress reflexive saccades to the sudden appearance of peripheral visual stimuli (prosaccades) and generate a saccade in the opposite direction. Recent imaging studies suggest that the globus pallidus (GP) is involved in the generation of antisaccades. To understand the roles of the GP, we examined single neuron activity and the effects of local inactivation. Monkeys were trained to make either a pro- or antisaccade according to prior instruction provided by the color of the fixation point in each trial. Among 119 saccade-related neurons, 55% showed increased firing rates associated with saccades, whereas the remaining neurons showed decreased firing rates. For both populations of neurons, the activity modulation was enhanced during the preparation and execution of antisaccades, as compared with prosaccades. Inactivation of the recording sites in the external segment of the GP resulted in an increase in the number of error trials in the antisaccade tasks, suggesting that signals in the GP may play roles in suppressing inadequate prosaccades in the task. Signals in the GP might regulate eye movements through the nigro-collicular descending circuitry and through the basal ganglia–thalamocortical pathways.

Key Words: antisaccade • globus pallidus • inactivation • physiology • primate


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Home page
 J. Neurophysiol.Home page
K. A. Ford and S. Everling
Neural Activity in Primate Caudate Nucleus Associated With Pro- and Antisaccades
J Neurophysiol, October 1, 2009; 102(4): 2334 - 2341.
[Abstract] [Full Text] [PDF]


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