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Cerebral Cortex Advance Access published online on January 29, 2008
Cerebral Cortex, doi:10.1093/cercor/bhm211
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Identification of Genetically Mediated Cortical Networks: A Multivariate Study of Pediatric Twins and Siblings

J. E. Schmitt1, R. K. Lenroot2, G. L. Wallace2, S. Ordaz2, K. N. Taylor2, N. Kabani4, D. Greenstein2, J. P. Lerch3, K. S. Kendler1, M. C. Neale1 and J. N. Giedd2

1 Virginia Institute for Psychiatric and Behavioral Genetics Richmond, VA 23298, USA, 2 National Institute of Mental Health Bethesda, MD 20892, USA, 3 Hospital for Sick Children Toronto, ON M5G 1X8, Canada, 4 Montreal Neurological Institute, Montreal, QC H3A 2B4, Canada

Address correspondence to Jay N. Giedd, MD, Chief, Brain Imaging Unit, Child Psychiatry Branch NIMH, Building 10, Room 4C110, 10 Center Drive, MSC 1367, Bethesda, MD 20892-1600, USA. Email: jg{at}nih.gov.

Structural magnetic resonance imaging data from 308 twins, 64 singleton siblings of twins, and 228 singletons were analyzed using structural equation modeling and selected multivariate methods to identify genetically mediated intracortical associations. Principal components analyses (PCA) of the genetic correlation matrix indicated a single factor accounting for over 60% of the genetic variability in cortical thickness. When covaried for mean global cortical thickness, PCA, cluster analyses, and graph models identified genetically mediated fronto-parietal and occipital networks. Graph theoretical models suggest that the observed genetically mediated relationships follow small world architectural rules. These findings are largely concordant with other multivariate studies of brain structure and function, the twin literature, and current understanding on the role of genes in cortical neurodevelopment.

Key Words: child development • genetics • neuroanatomy • small world


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