Skip Navigation



Cerebral Cortex Advance Access published online on June 8, 2007
Cerebral Cortex, doi:10.1093/cercor/bhm062
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
18/2/371    most recent
bhm062v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Wilson, T. W.
Right arrow Articles by Rojas, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilson, T. W.
Right arrow Articles by Rojas, D. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2007.

Cortical Gamma Generators Suggest Abnormal Auditory Circuitry in Early-Onset Psychosis

Tony W. Wilson1, Olivia O. Hernandez2, Ryan M. Asherin2, Peter D. Teale2, Martin L. Reite2 and Donald C. Rojas2

1 Magnetoencephalography Laboratory, Department of Neurology, Wake Forest University Health Sciences, Winston-Salem, NC, USA, 2 Neuromagnetic Imaging Center, Department of Psychiatry, University of Colorado, Health Sciences Center, Denver, CO, USA

Address correspondence to Tony W. Wilson, Ph.D., Magnetoencephalography Laboratory, Department of Neurology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. Email: Tony.W.Wilson{at}gmail.com.

Neurobiological theories of schizophrenia and related psychoses have increasingly emphasized impaired neuronal coordination (i.e., dysfunctional connectivity) as central to the pathophysiology. Although neuroimaging evidence has mostly corroborated these accounts, the basic mechanism(s) of reduced functional connectivity remains elusive. In this study, we examine the developmental trajectory and underlying mechanism(s) of dysfunctional connectivity by using gamma oscillatory power as an index of local and long-range circuit integrity. An early-onset psychosis group and a matched cohort of typically developing adolescents listened to monaurally presented click-trains, as whole-head magnetoencephalography data were acquired. Consistent with previous work, gamma-band power was significantly higher in right auditory cortices across groups and conditions. However, patients exhibited significantly reduced overall gamma power relative to controls, and showed a reduced ear-of-stimulation effect indicating that ipsi- versus contralateral presentation had less impact on hemispheric power. Gamma-frequency oscillations are thought to be dependent on gamma-aminobutyric acidergic interneuronal networks, thus these patients' impairment in generating and/or maintaining such activity may indicate that local circuit integrity is at least partially compromised early in the disease process. In addition, patients also showed abnormality in long-range networks (i.e., ear-of-stimulation effects) potentially suggesting that multiple stages along auditory pathways contribute to connectivity aberrations found in patients with psychosis.

Key Words: 40 Hz • bipolar • connectivity • magnetoencephalography • MEG • schizophrenia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Nerelius, A. Sandegren, H. Sargsyan, R. Raunak, H. Leijonmarck, U. Chatterjee, A. Fisahn, S. Imarisio, D. A. Lomas, D. C. Crowther, et al.
{alpha}-Helix targeting reduces amyloid-{beta} peptide toxicity
PNAS, June 9, 2009; 106(23): 9191 - 9196.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.