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Cerebral Cortex Advance Access published online on May 20, 2007
Cerebral Cortex, doi:10.1093/cercor/bhm044
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus

Dawn M. Eagle1, Christelle Baunez2, Daniel M. Hutcheson1, Olivia Lehmann1, Aarti P. Shah1 and Trevor W. Robbins1

1 Department of Experimental Psychology, University of Cambridge, Cambridge, UK, 2 CNRS, Laboratory of Neurobiology and Cognition, Marseille, France

Address correspondence to Dawn M. Eagle, PhD, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK. Email: d.eagle{at}psychol.cam.ac.uk.

The stop-signal reaction-time (SSRT) task measures inhibition of a response that has already been initiated, that is, the ability to stop. Human subjects classified as "impulsive," for example, those with attention deficit and hyperactivity disorder, are slower to respond to the stop signal. Although functional and structural imaging studies in humans have implicated frontal and basal ganglia circuitry in the mediation of this form of response control, the precise roles of the cortex and basal ganglia in SSRT performance are far from understood. We describe effects of excitotoxic fiber-sparing lesions of the orbitofrontal cortex (OF), infralimbic cortex (IL), and subthalamic nucleus (STN) in rats performing a SSRT task. Lesions to the OF slowed SSRT, whereas lesions to the IL or the STN had no effect. On the go-signal trials, neither cortical lesion affected go-trial reaction time (GoRT), but STN lesions speeded such latencies. The STN lesion also significantly reduced accuracy of stopping at all stop-signal delays, indicative of a generalized stopping impairment that was independent of the SSRT itself.

Key Words: infralimbic cortex • orbitofrontal cortex • prefrontal cortex • response inhibition • stop-signal reaction time • subthalamic nucleus


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