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Cerebral Cortex Advance Access published online on March 3, 2007
Cerebral Cortex, doi:10.1093/cercor/bhm012
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Neurofilament Protein and Neuronal Activity Markers Define Regional Architectonic Parcellation in the Mouse Visual Cortex

Estel Van der Gucht1,2, Patrick R. Hof2, Leen Van Brussel1, Kalina Burnat1,3 and Lutgarde Arckens1

1 Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium, 2 Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA, 3 Laboratory of Neuroplasticity, Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland

Address correspondence to Estel Van der Gucht, Laboratory of Neuroplasticity and Neuroproteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B-3000 Leuven, Belgium. Email: estel.vandergucht{at}bio.kuleuven.be.

This study was designed to assess the chemoarchitectural organization and extent of the mouse visual cortex. We used nonphosphorylated neurofilament protein, a neuronal marker that exhibits region-specific cellular and laminar patterns, to delineate cortical subdivisions. A comprehensive analysis demonstrated that pyramidal and nonpyramidal neurons expressing neurofilament proteins display striking laminar and regional patterns in the mouse visual cortex permitting the delineation of the primary visual cortex (V1) and its monocular and binocular zones, 2 lateral, and 5 medial extrastriate cortical areas with clear anatomical boundaries and providing evidence that the mouse medial extrastriate cortex is not homogeneous. We also investigated the expression profiles of 2 neuronal activity markers, the immediate early genes c-fos and zif-268, following deprivation paradigms to ascertain the visual nature of all subdivisions caudal, medial, and lateral to V1. The present data indicate that neurochemically identifiable subdivisions of the mouse visual cortex exist laterally and medially to V1 and reveal specific anatomical and functional characteristics at the cellular and regional levels.

Key Words: cortical organization • cytoarchitecture • immediate early genes • SMI-32 • visual cortex • visual deprivation


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