Skip Navigation



Cerebral Cortex Advance Access published online on September 1, 2006
Cerebral Cortex, doi:10.1093/cercor/bhl069
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
17/7/1582    most recent
bhl069v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Milh, M.
Right arrow Articles by Khazipov, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milh, M.
Right arrow Articles by Khazipov, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Rapid Cortical Oscillations and Early Motor Activity in Premature Human Neonate

Mathieu Milh 1, Anna Kaminska 2, Catherine Huon 3, Alexandre Lapillonne 3, Yehezkel Ben-Ari 1, and Rustem Khazipov 1 *

1 INMED/INSERM U29, Université de la Méditerranée, Marseille, France
2 Service de Physiologie et d'Exploration Fonctionnelle, Paris, France; INSERM U663, Université René Descartes, Paris, France
3 Service de Réanimation Néonatale, Groupe Hospitalier Cochin-Saint Vincent de Paul, Paris, France

* To whom correspondence should be addressed.
Rustem Khazipov, E-mail: khazipov{at}inmed.univ-mrs.fr


  Abstract

Delta-brush is the dominant pattern of rapid oscillatory activity (8-25 Hz) in the human cortex during the third trimester of gestation. Here, we studied the relationship between delta-brushes in the somatosensory cortex and spontaneous movements of premature human neonates of 29-31 weeks postconceptional age using a combination of scalp electroencephalography and monitoring of motor activity. We found that sporadic hand and foot movements heralded the appearance of delta-brushes in the corresponding areas of the cortex (lateral and medial regions of the contralateral central cortex, respectively). Direct hand and foot stimulation also reliably evoked delta-brushes in the same areas. These results suggest that sensory feedback from spontaneous fetal movements triggers delta-brush oscillations in the central cortex in a somatotopic manner. We propose that in the human fetus in utero, before the brain starts to receive elaborated sensory input from the external world, spontaneous fetal movements provide sensory stimulation and drive delta-brush oscillations in the developing somatosensory cortex contributing to the formation of cortical body maps.

Keywords: central cortex; delta-brush; EEG; fetus; myoclonic twitches.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J.-W. Yang, I. L. Hanganu-Opatz, J.-J. Sun, and H. J. Luhmann
Three Patterns of Oscillatory Activity Differentially Synchronize Developing Neocortical Networks In Vivo
J. Neurosci., July 15, 2009; 29(28): 9011 - 9025.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Minlebaev, Y. Ben-Ari, and R. Khazipov
NMDA Receptors Pattern Early Activity in the Developing Barrel Cortex In Vivo
Cereb Cortex, March 1, 2009; 19(3): 688 - 696.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Allene, A. Cattani, J. B. Ackman, P. Bonifazi, L. Aniksztejn, Y. Ben-Ari, and R. Cossart
Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex
J. Neurosci., November 26, 2008; 28(48): 12851 - 12863.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Rheims, M. Minlebaev, A. Ivanov, A. Represa, R. Khazipov, G. L. Holmes, Y. Ben-Ari, and Y. Zilberter
Excitatory GABA in Rodent Developing Neocortex In Vitro
J Neurophysiol, August 1, 2008; 100(2): 609 - 619.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Aronov, A. S. Andalman, and M. S. Fee
A Specialized Forebrain Circuit for Vocal Babbling in the Juvenile Songbird
Science, May 2, 2008; 320(5876): 630 - 634.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.