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Cerebral Cortex Advance Access published online on July 10, 2006
Cerebral Cortex, doi:10.1093/cercor/bhl038
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Cytochrome Oxidase and Neurofilament Reactivity in Monocularly Deprived Human Primary Visual Cortex

Kevin R. Duffy 1 *, Kathryn M. Murphy 2, Matthew P. Frosch 3, and Margaret S. Livingstone 4

1 Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
2 Department of Psychology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
3 C.S. Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
4 Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA

* To whom correspondence should be addressed.
Kevin R. Duffy, E-mail: kevin.duffy{at}dal.ca


  Abstract

Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.

Keywords: CO blobs; deprivation; human; neurofilament; ocular dominance columns; primary visual cortex.
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