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Cerebral Cortex Advance Access published online on July 3, 2006
Cerebral Cortex, doi:10.1093/cercor/bhl034
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Dopamine Modulation of Prefrontal Cortical Interneurons Changes during Adolescence

Kuei-Yuan Tseng 1 and Patricio O'Donnell 2 *

1 Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA; Current address: Department of Cellular and Molecular Pharmacology, Chicago Medical School/Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
2 Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA; Current address: Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

* To whom correspondence should be addressed.
Patricio O'Donnell, E-mail: odonnep{at}mail.amc.edu


  Abstract

Adolescence is marked by profound psychological and neuroendocrine changes. Cognitive functions that depend on the prefrontal cortex and dopamine (DA), such as decision making, are acquired or refined during adolescence; yet, little is known about how neural circuits mature in the transition to adulthood. Here, we conducted electrophysiological recordings in rat brain slices, unveiling an enhancement of the excitability of interneurons, which are important for cortical network activity, by D1 and D2 DA receptors. The D2 effect was observed in slices from adult (postnatal day [PD] > 50) but not preadolescent (PD < 36) animals suggesting a possible neural substrate for the maturation of DA-dependent prefrontal cortical functions during or after adolescence and identifying a critical neural population that could be involved in the periadolescent onset of neuropsychiatric disorders, such as schizophrenia.

Keywords: D1; D2; electrophysiology; GABA; schizophrenia.
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