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Cerebral Cortex Advance Access published online on May 26, 2006
Cerebral Cortex, doi:10.1093/cercor/bhl001
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Cortical Activity at Rest Predicts Cochlear Implantation Outcome

Hyo-Jeong Lee 1, Anne-Lise Giraud 2, Eunjoo Kang 3, Seung-Ha Oh 4 *, Hyejin Kang 5, Chong-Sun Kim 4, and Dong Soo Lee 5

1 Department of Otolaryngology, Seoul National University College of Medicine, Seoul, Korea; Inserm U742 ANiM, Université Pierre et Marie Curie (UPMC--Paris 6), Paris, France
2 Inserm U742 ANiM, Université Pierre et Marie Curie (UPMC--Paris 6), Paris, France
3 Department of Psychology, Kangwon National University, Chunchon, Korea
4 Department of Otolaryngology, Seoul National University College of Medicine, Seoul, Korea
5 Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

* To whom correspondence should be addressed.
Seung-Ha Oh, E-mail: shaoh{at}snu.ac.kr


  Abstract

The functional status of central neural pathways, in particular their susceptibility to plasticity and functional reorganization, may influence speech performance of deaf cochlear implant users. In this paper, we sought to determine how brain metabolic activity measured before implantation relates to cochlear implantation outcome, that is, speech perception. In 22 prelingually deaf children between 1 and 11 years, we correlated preoperative glucose metabolism as measured by F-18 fluorodeoxyglucose positron emission tomography with individual speech perception performance assessed 3 years after implantation, while factoring out the confounding effect of age at implantation. Whereas age at implantation was positively correlated with increased activity in the right superior temporal gyrus, speech scores were selectively associated with enhanced metabolic activity in the left prefrontal cortex and decreased metabolic activity in right Heschl's gyrus and in the posterior superior temporal sulcus. These results reinforce the notion that implantation should be performed as early as possible to prevent cross-modal takeover of auditory regions and suggest that rehabilitation strategies may be more efficient if they capitalize on general cognitive functions instead of only targeting specialized circuits dedicated to auditory and audiovisual pattern recognition.

Keywords: cochlear implants; deafness; positron emission tomography; speech perception.
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B. C. Papsin and K. A. Gordon
Cochlear Implants for Children with Severe-to-Profound Hearing Loss
N. Engl. J. Med., December 6, 2007; 357(23): 2380 - 2387.
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