Skip Navigation



Cerebral Cortex Advance Access published online on April 20, 2006
Cerebral Cortex, doi:10.1093/cercor/bhj178
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
17/3/531    most recent
bhj178v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tovar-Moll, F.
Right arrow Articles by Lent, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tovar-Moll, F.
Right arrow Articles by Lent, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Neuroplasticity in Human Callosal Dysgenesis: A Diffusion Tensor Imaging Study

Fernanda Tovar-Moll 1 *, Jorge Moll 2, Ricardo de Oliveira-Souza 2, Ivanei Bramati 2, Pedro A. Andreiuolo 2, and Roberto Lent 3

1 Department of Anatomy, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Cognitive and Behavioral Neuroscience Unit, Labs-D'Or Hospitals Network, Rio de Janeiro, Brazil
2 Cognitive and Behavioral Neuroscience Unit, Labs-D'Or Hospitals Network, Rio de Janeiro, Brazil
3 Department of Anatomy, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil

* To whom correspondence should be addressed.
Fernanda Tovar-Moll, E-mail: tovarmof{at}ninds.nih.gov


  Abstract

Callosal dysgenesis (CD) is observed in many neurodevelopmental conditions, but its subjacent mechanisms are unknown, despite extensive research on animals. Here we employ magnetic resonance diffusion tensor imaging and tractography in human CD to reveal the aberrant circuitry of these brains. We searched particularly for evidence of plasticity. Four main findings are described--1) in the presence of a callosal remnant or a hypoplastic corpus callosum (CC), fibers therein largely connect the expected neocortical regions; 2) callosal remnants and hypoplastic CCs display a fiber topography similar to normal; 3) at least 2 long abnormal tracts are formed in patients with defective CC: the well-known Probst bundle (PB) and a so far unknown sigmoid, asymmetrical aberrant bundle connecting the frontal lobe with the contralateral occipitoparietal cortex; and 4) whereas the PB is topographically organized and has an ipsilateral U-connectivity, the sigmoid bundle is a long, heterotopic commissural tract. These observations suggest that when the developing human brain is confronted with factors that hamper CC fibers to cross the midline, some properties of the miswired fibers are maintained (such as side-by-side topography), whereas others are dramatically changed, leading to the formation of grossly abnormal white matter tracts.

Keywords: callosal agenesis; callosal development; corpus callosum; cortex development; cortical commissures; DTI.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
L. Fuentemilla, E. Camara, T. F. Munte, U. M. Kramer, T. Cunillera, J. Marco-Pallares, C. Tempelmann, and A. Rodriguez-Fornells
Individual Differences in True and False Memory Retrieval Are Related to White Matter Brain Microstructure
J. Neurosci., July 8, 2009; 29(27): 8698 - 8703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
Y. Nakata, A.J. Barkovich, M. Wahl, Z. Strominger, R.J. Jeremy, M. Wakahiro, P. Mukherjee, and E.H. Sherr
Diffusion Abnormalities and Reduced Volume of the Ventral Cingulum Bundle in Agenesis of the Corpus Callosum: A 3T Imaging Study
AJNR Am. J. Neuroradiol., June 1, 2009; 30(6): 1142 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
J. J. McGrath and L. J. Richards
Why Schizophrenia Epidemiology Needs Neurobiology--and Vice Versa
Schizophr Bull, May 1, 2009; 35(3): 577 - 581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P.H. Tang, A.I. Bartha, M.E. Norton, A.J. Barkovich, E.H. Sherr, and O.A. Glenn
Agenesis of the Corpus Callosum: An MR Imaging Analysis of Associated Abnormalities in the Fetus
AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 257 - 263.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Wahl, Z. Strominger, R.J. Jeremy, A.J. Barkovich, M. Wakahiro, E.H. Sherr, and P. Mukherjee
Variability of Homotopic and Heterotopic Callosal Connectivity in Partial Agenesis of the Corpus Callosum: A 3T Diffusion Tensor Imaging and Q-Ball Tractography Study
AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 282 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P. Mukherjee, J.I. Berman, S.W. Chung, C.P. Hess, and R.G. Henry
Diffusion Tensor MR Imaging and Fiber Tractography: Theoretic Underpinnings
AJNR Am. J. Neuroradiol., April 1, 2008; 29(4): 632 - 641.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Ren, J. Zhang, C. Plachez, S. Mori, and L. J. Richards
Diffusion Tensor Magnetic Resonance Imaging and Tract-Tracing Analysis of Probst Bundle Structure in Netrin1- and DCC-Deficient Mice
J. Neurosci., September 26, 2007; 27(39): 10345 - 10349.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Marenco, M. A. Siuta, J. S. Kippenhan, S. Grodofsky, W.-l. Chang, P. Kohn, C. B. Mervis, C. A. Morris, D. R. Weinberger, A. Meyer-Lindenberg, et al.
Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome
PNAS, September 18, 2007; 104(38): 15117 - 15122.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.