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Cerebral Cortex Advance Access published online on February 15, 2006
Cerebral Cortex, doi:10.1093/cercor/bhj140
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Antisaccade Deficit after Inactivation of the Principal Sulcus in Monkeys

Carine Condy 1, Nicolas Wattiez 1, Sophie Rivaud-Péchoux 1, Léon Tremblay 1, and Bertrand Gaymard 2 *

1 Institut National de la Santé et de la Recherche Médicale U679, Universite Pierre and Marie Curie, France
2 Institut National de la Santé et de la Recherche Médicale U679, Universite Pierre and Marie Curie, France; Fédération de Neurophysiologie Clinique, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris cedex 13, France

* To whom correspondence should be addressed.
Bertrand Gaymard, E-mail: gaymard{at}ccr.jussieu.fr


  Abstract

The antisaccade (AS) task, which requires the ability to suppress unwanted reflexive glances, has proven to be a powerful tool for the analysis of executive control. Performing this task activates a large frontoparietal network, but which area is specifically responsible for reflexive saccade (RS) inhibition has not yet been demonstrated. We reversibly inactivated portions of the principal sulcus in 2 monkeys trained to perform AS and RS tasks. Here we show that inactivation of a circumscribed area in the ventral bank of the principal sulcus induced a strong impairment of RS inhibition without affecting RS triggering. Our results are compatible with a partitioning of the principal sulcus into functional subregions, in which a well-delineated area is critically involved in RS suppression.

Keywords: dorsolateral prefrontal cortex; frontal eye field; inhibitory control; muscimol; principal sulcus.
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