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Cerebral Cortex Advance Access published online on February 1, 2006
Cerebral Cortex, doi:10.1093/cercor/bhj123
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Large-Scale Visuomotor Integration in the Cerebral Cortex

Anders Ledberg 1, Steven L. Bressler 2 *, Mingzhou Ding 3, Richard Coppola 4, and Richard Nakamura 5

1 Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA; Departament de Tecnologia, Universitat Pompeu Fabra, 08003 Barcelona, Spain
2 Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
3 Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
4 Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
5 Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, USA

* To whom correspondence should be addressed.
Steven L. Bressler, E-mail: bressler{at}fau.edu


  Abstract

Efficient visuomotor behavior depends on integrated processing by the visual and motor systems of the cerebral cortex. Yet, many previous cortical neurophysiology studies have examined the visual and motor modalities in isolation, largely ignoring questions of large-scale cross-modal integration. To address this issue, we analyzed event-related local field potentials simultaneously recorded from multiple visual, motor, and executive cortical sites in monkeys performing a visuomotor pattern discrimination task. The timing and cortical location of four aspects of event-related activities were examined: stimulus-evoked activation onset, stimulus-specific processing, stimulus category-specific processing, and response-specific processing. Activations appeared earliest in striate cortex and rapidly thereafter in other visual areas. Stimulus-specific processing began early in most visual cortical areas, some at activation onset. Early onset latencies were also observed in motor, premotor, and prefrontal areas, some as early as in striate cortex, but these early-activating frontal sites did not show early stimulus-specific processing. Response-specific processing began around 150 ms poststimulus in widespread cortical areas, suggesting that perceptual decision formation and response selection arose through concurrent processes of visual, motor, and executive areas. The occurrence of stimulus-specific and stimulus category-specific differences after the onset of response-specific processing suggests that sensory and motor stages of visuomotor processing overlapped in time.

Keywords: event-related potentials; local field potentials; prefrontal cortex; timing; visual pathways.
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