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Cerebral Cortex Advance Access published online on January 18, 2006
Cerebral Cortex, doi:10.1093/cercor/bhj113
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Differential Functions of Lateral and Medial Rostral Prefrontal Cortex (Area 10) Revealed by Brain-Behavior Associations

Sam J. Gilbert 1 *, Stephanie Spengler 1, Jon S. Simons 1, Christopher D. Frith 2, and Paul W. Burgess 1

1 Institute of Cognitive Neuroscience and Department of Psychology, Institute of Neurology, University College London, London, UK
2 Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK

* To whom correspondence should be addressed.
Sam J. Gilbert, E-mail: sam.gilbert{at}ucl.ac.uk


  Abstract

We analyzed the behavioral data from 104 neuroimaging studies using positron emission tomography or functional magnetic resonance imaging that reported activation peaks in rostral prefrontal cortex (PFC), approximating Brodmann's area 10. The distribution of absolute x coordinates of activation peaks (i.e., x coordinate regardless of hemisphere) differed significantly from a unimodal normal distribution, reflecting distinct clusters of activation in lateral and medial subregions. These 2 clusters were associated with different patterns of behavioral data. Lateral activations were associated with contrasts between experimental and control conditions where response times (RTs) were slower in the experimental condition. Medial activations were associated with contrasts where RTs were, if anything, faster in experimental than control conditions. These findings place important constraints on theories of rostral PFC functions.

Keywords: Brodmann's area 10; fMRI; frontal pole; meta-analysis; PET; response time.
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