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Cerebral Cortex Advance Access published online on December 28, 2005
Cerebral Cortex, doi:10.1093/cercor/bhj097
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Article

Role of Prefrontal and Anterior Cingulate Regions in Decision-Making Processes Shared by Memory and Nonmemory Tasks

Mathias S. Fleck 1, Sander M. Daselaar 1, Ian G. Dobbins 2, and Roberto Cabeza 1 *

1 Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA; Department of Psychological and Brain Sciences, Duke University, Durham, NC 27708, USA
2 Department of Psychological and Brain Sciences, Duke University, Durham, NC 27708, USA

* To whom correspondence should be addressed.
Roberto Cabeza, E-mail: cabeza{at}duke.edu


  Abstract

In the episodic retrieval (ER) domain, activations in right dorsolateral prefrontal cortex (DLPFC) are often attributed to postretrieval monitoring. Yet, right DLPFC activations are also frequently found during nonmemory tasks. To investigate the role of this region across different cognitive functions, we directly compared brain activity during ER and visual perception (VP) using event-related functional magnetic resonance imaging. In the ER task, participants decided whether words were old or new, whereas in the VP task, they decided which of the two colored screen areas was larger. In both tasks, each decision was followed by a confidence rating. The main finding was that right DLPFC (Brodmann area 46/10) activity was greater for low- than for high-confidence decisions in both tasks, demonstrating a general role in decision making. Even when reaction times (RTs) were included in the model, confidence remained the significant predictor of activity, suggesting that right DLPFC is involved in discontinuous evaluation rather than in continuous monitoring. In contrast, activity in anterior cingulate cortex was not only greater for low-confidence decisions but also increased with RT, reflecting a role in continuous conflict monitoring. Overall, the results demonstrate how direct cross-function comparisons clarify the generality and specificity of the functions of various brain regions.

Keywords: confidence; dorsolateral; episodic; parametric fMRI; reaction time.
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