Skip Navigation



Cerebral Cortex Advance Access published online on December 28, 2005
Cerebral Cortex, doi:10.1093/cercor/bhj095
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
16/11/1584    most recent
bhj095v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Rettmann, M. E.
Right arrow Articles by Resnick, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rettmann, M. E.
Right arrow Articles by Resnick, S. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2005.

Article

Cross-sectional and Longitudinal Analyses of Anatomical Sulcal Changes Associated with Aging

Maryam E. Rettmann 1 *, Michael A. Kraut 2, Jerry L. Prince 3, and Susan M. Resnick 4

1 National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
2 Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
3 Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
4 National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA

* To whom correspondence should be addressed.
Maryam E. Rettmann, E-mail: maryam.rettmann{at}nih.gov


  Abstract

Imaging studies of the human brain indicate that the cortex undergoes anatomic changes during the aging process. With the ability to study the human brain in vivo using magnetic resonance imaging, understanding the nature and location of these changes is of increasing interest. In this work, we investigate cross-sectional and longitudinal age effects on the geometric shape and gray matter (GM) volume for regions of interest on the cortical surface. Each of the regions corresponds to the buried cortex surrounding the sulcal spaces and is termed a "sulcal region." The study consists of 35 older adults scanned three times over a 4-year time span. The group includes 19 women and 16 men ranging in ages from 59 to 84 years (mean 70.9, standard deviation 6.2). We analyze 8 sulcal regions--the buried cortex surrounding the left and right central, superior frontal, cingulate, and parietooccipital sulci. We examine surface area, GM thickness, GM volume, sulcal depth, local gyrification index, and measures of curvature. Results indicate cross-sectional age effects in mean thickness, GM volume, sulcal depth, and curvature characteristics of sulcal regions. In addition, we found longitudinal decreases in surface area, mean thickness, GM volume, and sulcal depth measures as well as changes in sulcal curvature.

Keywords: aging; brain; cortex; cortical atrophy; cortical shape changes; sulci.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cogn. Neurosci.Home page
A. Hampshire, A. Gruszka, S. J. Fallon, and A. M. Owen
Inefficiency in Self-organized Attentional Switching in the Normal Aging Population is Associated with Decreased Activity in the Ventrolateral Prefrontal Cortex
J. Cogn. Neurosci., September 1, 2008; 20(9): 1670 - 1686.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. D. Cykowski, O. Coulon, P. V. Kochunov, K. Amunts, J. L. Lancaster, A. R. Laird, D. C. Glahn, and P. T. Fox
The Central Sulcus: an Observer-Independent Characterization of Sulcal Landmarks and Depth Asymmetry
Cereb Cortex, September 1, 2008; 18(9): 1999 - 2009.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. Im, J.-M. Lee, O. Lyttelton, S. H. Kim, A. C. Evans, and S. I. Kim
Brain Size and Cortical Structure in the Adult Human Brain
Cereb Cortex, September 1, 2008; 18(9): 2181 - 2191.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Jouvent, J.-F. Mangin, R. Porcher, A. Viswanathan, M. O'Sullivan, J.-P. Guichard, M. Dichgans, M.-G. Bousser, and H. Chabriat
Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASIL
Brain, August 1, 2008; 131(8): 2201 - 2208.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.