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Cerebral Cortex Advance Access published online on August 17, 2005
Cerebral Cortex, doi:10.1093/cercor/bhj018
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Article

Cortical Intrinsic Circuits Can Support Activity Propagation through an Isofrequency Strip of the Guinea Pig Primary Auditory Cortex

Wen-Jie Song 1*, Hideo Kawaguchi 2, Shinichiro Totoki 1, Yuji Inoue 1, Takusige Katura 2, Shinichi Maeda 1, Shinji Inagaki 1, Hiroshi Shirasawa 1, and Masataka Nishimura 1

1 Department of Electronic Engineering, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan
2 Advanced Research Laboratory, Hitachi, Ltd., Saitama 350-0395, Japan

* To whom correspondence should be addressed.
Wen-Jie Song, E-mail: song{at}ele.eng.osaka-u.ac.jp


  Abstract

A pure tone evokes propagating activities in a strip of the primary auditory cortex (AI), an isofrequency strip (IS). A fundamental issue concerns the roles that thalamocortical input and intracortical connectivity play in generating the activities. Here we addressed this issue in guinea pigs using in vivo and in vitro real-time optical imaging techniques. As reported previously, tone-evoked activity propagated dorsoventrally along a strip (an IS) in AI. We found that an electrical pulse applied focally within the strip, triggered activity propagation with a spatiotemporal pattern highly similar to tone-evoked activation. The propagation velocity of electrically evoked activity was significantly slower than that of tone-evoked activity, but was comparable to the velocity of lateral activity propagation in cortical slices, suggesting that the electrically evoked activity propagation in vivo is mediated by intracortical circuits. To test this notion, we lesioned the auditory thalamus chemically; in such animals, electrically evoked activity in AI was not affected, although tone-evoked activity was abolished. Further, in slices of the AI, the extent of electrically evoked activity propagation in layer II/III was significantly larger in coronal slices than in horizontal slices. Together, our results suggest that intracortical connectivity in AI enables a focally evoked activity to propagate throughout an IS.

Keywords: cortical dynamics; electrical stimulation; intracortical circuits; optical recording; propagating activity.
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