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Cerebral Cortex Advance Access published online on May 18, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi112
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Article

Parasagittal Asymmetries of the Corpus Callosum

E. Luders 1, K.L. Narr 1, E. Zaidel 2, P.M. Thompson 1, L. Jancke 3, and A.W. Toga 1*

1 Laboratory of Neuro Imaging, Department of Neurology, Brain Mapping Division, UCLA School of Medicine, Los Angeles, USA
2 Department of Psychology, UCLA, Los Angeles, USA
3 Department of Neuropsychology, University of Zurich, Switzerland

* To whom correspondence should be addressed.
A.W. Toga, E-mail: toga{at}loni.ucla.edu


  Abstract

Significant relationships have been reported between midsagittal areas of the corpus callosum and the degree of interhemispheric transfer, functional lateralization and structural brain asymmetries. No study, however, has examined whether parasagittal callosal asymmetries (i.e. those close to the midline of the brain), which may be of specific functional consequence, are present in the human brain. Thus, we applied magnetic resonance imaging and novel computational surface-based methods to encode hemispheric differences in callosal thickness at a very high resolution. Discrete callosal areas were also compared between the hemispheres. Furthermore, acknowledging the frequently reported sex differences in callosal morphology, parasagittal callosal asymmetries were examined within each gender. Results showed significant rightward asymmetries of callosal thickness predominantly in the anterior body and anterior third of the callosum, suggesting a more diffuse functional organization of callosal projections in the right hemisphere. Asymmetries were increased in men, supporting the assumption of a sexually dimorphic organization of male and female brains that involves hemispheric relations and is reflected in the organization and distribution of callosal fibers.

Keywords: gender; lateralization; hemispheres; morphology; sex.
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