Cerebral Cortex Advance Access published online on May 4, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi100
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 C. & O. Vogt Institute for Brain Research, University of Düsseldorf, POB 101007, D-40001 Düsseldorf, Germany
* To whom correspondence should be addressed. Cortical layer V classically has been subdivided into sublayers Va and Vb on cytoarchitectonic grounds. In the analysis of cortical microcircuits, however, layer Va has largely been ignored. The purpose of this study was to investigate pyramidal neurons of layer Va in view of their potential role in integrating information from lemniscal and paralemniscal sources. For this we combined detailed electrophysiological and morphological characterization with mapping of intracortical functional connectivity by caged glutamate photolysis in layer Va of rat barrel cortex in vitro. Electrophysiological characterization revealed pyramidal cells of the regular spiking as well as the intrinsically burst firing type. However, all layer Va pyramidal neurons displayed uniform morphological properties and comparable functional input connectivity patterns. They received most of their excitatory and inhibitory inputs from intracolumnar sources, especially from layer Va itself, but also from layer IV. Those two layers were also the main origin for transcolumnar excitatory inputs. Layer Va pyramidal neurons thus may predominantly integrate information intralaminarly as well as from layer IV. The functional connectivity maps clearly distinguish layer Va from layer Vb pyramidal cells, and suggest that layer Va plays a unique role in intracortical processing of sensory information.
Article
Morphology, Electrophysiology and Functional Input Connectivity of Pyramidal Neurons Characterizes a Genuine Layer Va in the Primary Somatosensory Cortex
2 C. & O. Vogt Institute for Brain Research, University of Düsseldorf, POB 101007, D-40001 Düsseldorf, Germany; Institute of Anatomy II, University of Düsseldorf, POB 101007, D-40001 Düsseldorf, Germany
3 Institute of Physiology and Pathophysiology, University of Mainz, Düsbergweg 6, D-55128 Mainz, Germany
D. Schubert, E-mail: schubd{at}uni-duesseldorf.de
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. A. Llano and S. M. Sherman Differences in Intrinsic Properties and Local Network Connectivity of Identified Layer 5 and Layer 6 Adult Mouse Auditory Corticothalamic Neurons Support a Dual Corticothalamic Projection Hypothesis Cereb Cortex, December 1, 2009; 19(12): 2810 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. J. de Kock and B. Sakmann Spiking in primary somatosensory cortex during natural whisking in awake head-restrained rats is cell-type specific PNAS, September 22, 2009; 106(38): 16446 - 16450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Giaume, M. Maravall, E. Welker, and G. Bonvento The Barrel Cortex as a Model to Study Dynamic Neuroglial Interaction Neuroscientist, August 1, 2009; 15(4): 351 - 366. [Abstract] [PDF]
|
|
|
|
|
|
A. Groh, H. S. Meyer, E. F. Schmidt, N. Heintz, B. Sakmann, and P. Krieger Cell-Type Specific Properties of Pyramidal Neurons in Neocortex Underlying a Layout that Is Modifiable Depending on the Cortical Area Cereb Cortex, July 30, 2009; (2009) bhp152v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. N. Karameh and S. G. Massaquoi Intracortical Augmenting Responses in Networks of Reduced Compartmental Models of Tufted Layer 5 Cells J Neurophysiol, January 1, 2009; 101(1): 207 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Otsuka and Y. Kawaguchi Firing-Pattern-Dependent Specificity of Cortical Excitatory Feed-Forward Subnetworks J. Neurosci., October 29, 2008; 28(44): 11186 - 11195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Helmstaedter, J. F. Staiger, B. Sakmann, and D. Feldmeyer Efficient Recruitment of Layer 2/3 Interneurons by Layer 4 Input in Single Columns of Rat Somatosensory Cortex J. Neurosci., August 13, 2008; 28(33): 8273 - 8284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. J. de Kock and B. Sakmann High frequency action potential bursts (>= 100 Hz) in L2/3 and L5B thick tufted neurons in anaesthetized and awake rat primary somatosensory cortex J. Physiol., July 15, 2008; 586(14): 3353 - 3364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Alloway Information Processing Streams in Rodent Barrel Cortex: The Differential Functions of Barrel and Septal Circuits Cereb Cortex, May 1, 2008; 18(5): 979 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Frick, D. Feldmeyer, M. Helmstaedter, and B. Sakmann Monosynaptic Connections between Pairs of L5A Pyramidal Neurons in Columns of Juvenile Rat Somatosensory Cortex Cereb Cortex, February 1, 2008; 18(2): 397 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Frick, D. Feldmeyer, and B. Sakmann Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex J. Physiol., November 15, 2007; 585(1): 103 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Chang and J. I. Luebke Electrophysiological Diversity of Layer 5 Pyramidal Cells in the Prefrontal Cortex of the Rhesus Monkey: In Vitro Slice Studies J Neurophysiol, November 1, 2007; 98(5): 2622 - 2632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watakabe, N. Ichinohe, S. Ohsawa, T. Hashikawa, Y. Komatsu, K. S. Rockland, and T. Yamamori Comparative Analysis of Layer-Specific Genes in Mammalian Neocortex Cereb Cortex, August 1, 2007; 17(8): 1918 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Schubert Observing without disturbing: how different cortical neuron classes represent tactile stimuli J. Physiol., May 15, 2007; 581(1): 5 - 5. [Full Text] [PDF]
|
|
|
|
|
|
C. P. J. de Kock, R. M. Bruno, H. Spors, and B. Sakmann Layer- and cell-type-specific suprathreshold stimulus representation in rat primary somatosensory cortex J. Physiol., May 15, 2007; 581(1): 139 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Derdikman, C. Yu, S. Haidarliu, K. Bagdasarian, A. Arieli, and E. Ahissar Layer-Specific Touch-Dependent Facilitation and Depression in the Somatosensory Cortex during Active Whisking. J. Neurosci., September 13, 2006; 26(37): 9538 - 9547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Feldmeyer, J. Lubke, and B. Sakmann Efficacy and connectivity of intracolumnar pairs of layer 2/3 pyramidal cells in the barrel cortex of juvenile rats J. Physiol., September 1, 2006; 575(2): 583 - 602. [Abstract] [Full Text] [PDF]
|
|