Skip Navigation



Cerebral Cortex Advance Access published online on March 23, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi075
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/12/2003    most recent
bhi075v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Badre, D.
Right arrow Articles by Wagner, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Badre, D.
Right arrow Articles by Wagner, A. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Article

Frontal Lobe Mechanisms that Resolve Proactive Interference

David Badre 1* and Anthony D. Wagner 2

1 Department of Psychology and Neurosciences Program, Stanford University, Stanford, CA 94305, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
2 Department of Psychology and Neurosciences Program, Stanford University, Stanford, CA 94305, USA; Martinos Center for Biomedical Imaging, MGH/MIT/HMS, Charlestown, MA, USA

* To whom correspondence should be addressed.
David Badre, E-mail: badred{at}mit.edu


  Abstract

Memory of a past experience can interfere with processing during a subsequent experience, a phenomenon termed proactive interference (PI). Neuroimaging and neuropsychological evidence implicate the left mid-ventrolateral prefrontal cortex (mid-VLPFC) in PI resolution during short-term item recognition, though the precise mechanisms await specification. The present functional magnetic resonance imaging (fMRI) experiment sought to further constrain theorizing regarding PI resolution. On each trial, subjects maintained a target set of words, and then decided if a subsequent probe was contained in the target set (positive) or not (negative). Importantly, for half of the negative and half of the positive trials, the probe had been contained in the previous target set (recent). Relative to non-recent trials, negative-recent trials produced an increase in response times and error rates, behavioral markers of PI. In fMRI measures, negative recency was associated with increased activation in the left mid-VLPFC, as well as in the bilateral fronto-polar cortex, providing evidence for multiple components in PI resolution. Furthermore, recency effects were evident during both negative and positive trials, with the magnitude of the recency effect in the mid-VLPFC being greater on negative trials. Collectively, these results serve to specify and constrain proposed models of PI resolution.

Keywords: cognitive control; episodic memory; executive function; prefrontal cortex; working memory.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
D. M. Barch, M. G. Berman, R. Engle, J. H. Jones, J. Jonides, A. MacDonald III, D. E. Nee, T. S. Redick, and S. R. Sponheim
CNTRICS Final Task Selection: Working Memory
Schizophr Bull, January 1, 2009; 35(1): 136 - 152.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Xue, D. G. Ghahremani, and R. A. Poldrack
Neural Substrates for Reversing Stimulus-Outcome and Stimulus-Response Associations
J. Neurosci., October 29, 2008; 28(44): 11196 - 11204.
[Abstract] [Full Text] [PDF]

Home page
 Cogn Affect Behav NeurosciHome page
C. L. FALES, D. M. BARCH, G. C. BURGESS, A. SCHAEFER, D. S. MENNIN, J. R. GRAY, and T. S. BRAVER
Anxiety and cognitive efficiency: Differential modulation of transient and sustained neural activity during a working memory task
Cogn Affect Behav Neurosci, September 1, 2008; 8(3): 239 - 253.
[Abstract] [PDF]

Home page
 Learn. Mem.Home page
M. G. Baxter, P. G.F. Browning, and A. S. Mitchell
Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex
Learn. Mem., March 1, 2008; 15(3): 126 - 132.
[Abstract] [Full Text] [PDF]

Home page
 Mem CognitHome page
A. S. ATKINS and P. A. REUTER-LORENZ
False working memories? Semantic distortion in a mere 4 seconds
Mem Cognit, January 1, 2008; 36(1): 74 - 81.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
J. B. Caplan, A. R. McIntosh, and E. De Rosa
Two Distinct Functional Networks for Successful Resolution of Proactive Interference
Cereb Cortex, July 1, 2007; 17(7): 1650 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Kostopoulos, M.-C. Albanese, and M. Petrides
Ventrolateral prefrontal cortex and tactile memory disambiguation in the human brain
PNAS, June 12, 2007; 104(24): 10223 - 10228.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
R. S. Blumenfeld and C. Ranganath
Prefrontal Cortex and Long-Term Memory Encoding: An Integrative Review of Findings from Neuropsychology and Neuroimaging
Neuroscientist, June 1, 2007; 13(3): 280 - 291.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Feredoes, G. Tononi, and B. R. Postle
Direct evidence for a prefrontal contribution to the control of proactive interference in verbal working memory
PNAS, December 19, 2006; 103(51): 19530 - 19534.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Badre and A. D. Wagner
Computational and neurobiological mechanisms underlying cognitive flexibility
PNAS, May 2, 2006; 103(18): 7186 - 7191.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.