Skip Navigation



Cerebral Cortex Advance Access published online on February 23, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi054
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/11/1768    most recent
bhi054v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dobbins, I. G.
Right arrow Articles by Wagner, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dobbins, I. G.
Right arrow Articles by Wagner, A. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Article

Domain-general and Domain-sensitive Prefrontal Mechanisms for Recollecting Events and Detecting Novelty

Ian G. Dobbins 1* and Anthony D. Wagner 2

1 Psychological and Brain Sciences, Duke University, Durham, NC 27708, USA
2 Department of Psychology and Neurosciences Program, Stanford University, Stanford, CA 94305, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA

* To whom correspondence should be addressed.
Ian G. Dobbins, E-mail: ian{at}psych.duke.edu


  Abstract

Recollecting the past and discriminating novel from familiar memoranda depend on poorly understood prefrontal cortical (PFC) mechanisms hypothesized to vary according to memory task (e.g. recollection versus novelty detection) and domain of targeted memories (e.g. perceptual versus conceptual). Using event-related fMRI, we demonstrate that recollecting conceptual or perceptual details surrounding object encounters similarly recruits left frontopolar and posterior PFC compared with detecting novel stimuli, suggesting that a domain-general control network is engaged during contextual remembering. In contrast, left anterior ventrolateral PFC coactivated with a left middle temporal region associated with semantic representation, and right ventrolateral PFC with bilateral occipito-temporal cortices associated with representing object form, depending on whether recollections were conceptual or perceptual. These PFC/posterior cortical dissociations suggest that during recollection, lateralized ventrolateral PFC mechanisms bias posterior conceptual or perceptual feature representations as a function of memory relevance, potentially improving the gain of bottom-up memory signals. Supporting this domain-sensitive biasing hypothesis, novelty detection also recruited right ventrolateral PFC and bilateral occipito-temporal cortices compared with conceptual recollection, suggesting that searching for novel objects heavily relies upon perceptual feature processing. Collectively, these data isolate task- from domain-sensitive PFC control processes strategically recruited in the service of episodic memory.

Keywords: attention; cognitive control; familiarity; fMRI; memory; prefrontal cortex.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
E. A. Race, D. Badre, and A. D. Wagner
Multiple Forms of Learning Yield Temporally Distinct Electrophysiological Repetition Effects
Cereb Cortex, November 13, 2009; (2009) bhp233v1.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. Whitney, M. Grossman, and T. T. J. Kircher
The Influence of Multiple Primes on Bottom-Up and Top-Down Regulation during Meaning Retrieval: Evidence for 2 Distinct Neural Networks
Cereb Cortex, November 1, 2009; 19(11): 2548 - 2560.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. K. Olsen, E. A. Nichols, J. Chen, J. F. Hunt, G. H. Glover, J. D. E. Gabrieli, and A. D. Wagner
Performance-Related Sustained and Anticipatory Activity in Human Medial Temporal Lobe during Delayed Match-to-Sample
J. Neurosci., September 23, 2009; 29(38): 11880 - 11890.
[Abstract] [Full Text] [PDF]

Home page
 Cogn Affect Behav NeurosciHome page
M. Rosenberg-Lee, M. C. Lovett, and J. R. Anderson
Neural correlates of arithmetic calculation strategies
Cogn Affect Behav Neurosci, September 1, 2009; 9(3): 270 - 285.
[Abstract] [PDF]

Home page
 Learn. Mem.Home page
J. B. Hutchinson, M. R. Uncapher, and A. D. Wagner
Posterior parietal cortex and episodic retrieval: Convergent and divergent effects of attention and memory
Learn. Mem., May 23, 2009; 16(6): 343 - 356.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. G. R. McDuff, H. C. Frankel, and K. A. Norman
Multivoxel Pattern Analysis Reveals Increased Memory Targeting and Reduced Use of Retrieved Details during Single-Agenda Source Monitoring
J. Neurosci., January 14, 2009; 29(2): 508 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Emotion ReviewHome page
E. A. Kensinger
Remembering the Details: Effects of Emotion.
Emotion Review, January 1, 2009; 1(2): 99 - 113.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
J. F. Danker, P. Gunn, and J. R. Anderson
A Rational Account of Memory Predicts Left Prefrontal Activation during Controlled Retrieval
Cereb Cortex, November 1, 2008; 18(11): 2674 - 2685.
[Abstract] [Full Text] [PDF]

Home page
 Cogn Affect Behav NeurosciHome page
B. A. KUHL, I. KAHN, N. M. DUDUKOVIC, and A. D. WAGNER
Overcoming suppression in order to remember: Contributions from anterior cingulate and ventrolateral prefrontal cortex
Cogn Affect Behav Neurosci, June 1, 2008; 8(2): 211 - 221.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
J. R. Anderson, D. Byrne, J. M. Fincham, and P. Gunn
Role of Prefrontal and Parietal Cortices in Associative Learning
Cereb Cortex, April 1, 2008; 18(4): 904 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. M. Daselaar, H. J. Rice, D. L. Greenberg, R. Cabeza, K. S. LaBar, and D. C. Rubin
The Spatiotemporal Dynamics of Autobiographical Memory: Neural Correlates of Recall, Emotional Intensity, and Reliving
Cereb Cortex, January 1, 2008; 18(1): 217 - 229.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. E. Berryhill, L. Phuong, L. Picasso, R. Cabeza, and I. R. Olson
Parietal Lobe and Episodic Memory: Bilateral Damage Causes Impaired Free Recall of Autobiographical Memory
J. Neurosci., December 26, 2007; 27(52): 14415 - 14423.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
R. J. Garoff-Eaton, E. A. Kensinger, and D. L. Schacter
The neural correlates of conceptual and perceptual false recognition
Learn. Mem., October 1, 2007; 14(10): 684 - 692.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
R. S. Blumenfeld and C. Ranganath
Prefrontal Cortex and Long-Term Memory Encoding: An Integrative Review of Findings from Neuropsychology and Neuroimaging
Neuroscientist, June 1, 2007; 13(3): 280 - 291.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
B. T. Gold, D. A. Balota, S. J. Jones, D. K. Powell, C. D. Smith, and A. H. Andersen
Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions.
J. Neurosci., June 14, 2006; 26(24): 6523 - 6532.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Badre and A. D. Wagner
Computational and neurobiological mechanisms underlying cognitive flexibility
PNAS, May 2, 2006; 103(18): 7186 - 7191.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.