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Cerebral Cortex Advance Access published online on February 9, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi041
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Article

Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development

Ralf S. Schmid 1, Rebecca Jo 1, Stephanie Shelton 1, Jordan A. Kreidberg 2, and E. S. Anton 1*

1 UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
2 Department of Medicine, Children's Hospital, Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA

* To whom correspondence should be addressed.
E. S. Anton, E-mail: anton{at}med.unc.edu


  Abstract

Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as {alpha}3{beta}1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that {alpha}3{beta}1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of {beta}1 integrin in a reelin-dependent manner. Thus, {alpha}3{beta}1 integrin-reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.

Keywords: cerebral cortex; Dab1; integrin; neuronal migration; reelin.
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