Skip Navigation



Cerebral Cortex Advance Access published online on February 2, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi030
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/10/1510    most recent
bhi030v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Eliades, S. J.
Right arrow Articles by Wang, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eliades, S. J.
Right arrow Articles by Wang, X.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Article

Dynamics of Auditory-Vocal Interaction in Monkey Auditory Cortex

Steven J. Eliades 1 and Xiaoqin Wang 1*

1 Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

* To whom correspondence should be addressed.
Xiaoqin Wang, E-mail: xwang{at}bme.jhu.edu


  Abstract

Single neurons in the primate auditory cortex exhibit vocalization-related modulations (excitatory or inhibitory) during self-initiated vocal production. Previous studies have shown that these modulations of cortical activity are variable in individual neurons' responses to multiple instances of vocalization and diverse between different cortical neurons. The present study investigated dynamic patterns of vocalization-related modulations and demonstrated that much of the variability in cortical modulations was related to the acoustic structures of self-produced vocalization. We found that suppression of single unit activity during multi-phrased vocalizations was temporally specific in that it was maintained during each phrase, but was released between phrases. Furthermore, the degree of suppression or excitation was correlated to the mean energy and frequency of the produced vocalizations, accounting for much of the response variability between multiple instances of vocalization. Simultaneous recordings of pairs of neurons from a single electrode revealed that the modulations by self-produced vocalizations in nearby neurons were largely uncorrelated. Additionally, vocalization-induced suppression was found to be preferentially distributed to upper cortical layers. Finally, we showed that the summation of all auditory cortical activity during vocalization, including both single and multi-unit responses, was weakly excitatory, consistent with observations from studies of the human brain during speech.

Keywords: feedback; marmoset; sensory-motor interaction; vocalization; vocal production.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
K. E. Watkins, S. M. Smith, S. Davis, and P. Howell
Structural and functional abnormalities of the motor system in developmental stuttering
Brain, January 1, 2008; 131(1): 50 - 59.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.