Cerebral Cortex Advance Access first published online on January 12, 2005
This version published online on February 4, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi024
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1 Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, KY, USA; Department of Psychology, Washington University, School of Medicine, St. Louis, MO, USA; Howard Hughes Medical Institute, USA
* To whom correspondence should be addressed. Recent evidence suggests specialization of anterior left inferior prefrontal cortex (aLIPC;
Article
Common and Dissociable Activation Patterns Associated with Controlled Semantic and Phonological Processing: Evidence from fMRI Adaptation
2 Department of Psychology, Washington University, School of Medicine, St. Louis, MO, USA
3 Department of Psychology, Washington University, School of Medicine, St. Louis, MO, USA; Howard Hughes Medical Institute, USA; Departments of Radiology and Anatomy & Neurobiology, Washington University, School of Medicine, St. Louis, MO, USA
Brian T. Gold, E-mail: brian.gold{at}uky.edu
Abstract 
BA 45/47) for controlled semantics and of posterior LIPC (pLIPC; BA 44/6) for controlled phonology. However, the more automated phonological tasks commonly used raise the possibility that some of the typically extensive aLIPC activation during semantic tasks may relate to controlled language processing beyond the semantic domain. In the present study, an event-related fMRI adaptation paradigm was employed that used a standard controlled semantic task and a phonological task that also emphasized controlled processing. When compared with letter (baseline) processing, significant fMRI task and adaptation effects in the aLIPC and pLIPC regions (BA 45/47, BA 44) were observed during both semantic and phonological processing, with aLIPC showing the strongest effects during semantic processing. A left frontal region (BA 6) showed task and relative adaptation effects preferential for phonological processing, and a left temporal region (BA 21) showed task and relative adaptation effects preferential for semantic processing. Our results demonstrate that aLIPC and pLIPC regions are involved in controlled processing across multiple language domains, arguing against a domain-specific LIPC model and for domain-preferentiality in left posterior frontal and temporal regions.
Table 1 has been corrected.
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