Cerebral Cortex Advance Access published online on January 5, 2005
Cerebral Cortex, doi:10.1093/cercor/bhi018
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Health Sciences, Boston University, Boston, MA, USA; Program in Neuroscience, Boston University, Boston, MA, USA; NEPRC, Harvard Medical School, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
* To whom correspondence should be addressed. The prefrontal cortex selects relevant signals and suppresses irrelevant signals in behavior, as exemplified by its functional interaction with superior temporal cortices. We addressed the structural basis of this process by investigating quantitatively the relationship of prefrontal pathways to inhibitory interneurons in superior temporal cortices. Pathways were labeled with neural tracers, and two neurochemical classes of inhibitory interneurons were labeled with parvalbumin (PV) and calbindin (CB), which differ in mode of inhibitory control. Both markers varied significantly and systematically across superior temporal areas. Calbindin neurons were more prevalent than PV neurons, with the highest densities found in posterior high-order auditory association cortices. Axons from anterior lateral, medial prefrontal and orbitofrontal areas terminated in the anterior half of the superior temporal gyrus, targeting mostly the superficial layers (I to upper III), where CB neurons predominated. Reciprocal projection neurons were intermingled with PV neurons, and emanated mostly from the deep part of layer III and to a lesser extent from layers V-VI, in proportions matching the laminar density of inhibitory interneurons. In marked contrast, prefrontal connections in temporal polar cortex were found mostly in the deep layers, showing mismatch with the predominant upper laminar distribution of interneurons. Differences in the relationship of connections to inhibitory neurons probably affect the dynamics in distinct superior temporal cortices. These findings may help explain the reduced efficacy of inhibitory control in superior temporal areas after prefrontal cortical damage.
Article
Relationship of Prefrontal Connections to Inhibitory Systems in Superior Temporal Areas in the Rhesus Monkey
2 Department of Health Sciences, Boston University, Boston, MA, USA
H. Barbas, E-mail: barbas{at}bu.edu
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Kazama and J. Bachevalier Selective Aspiration or Neurotoxic Lesions of Orbital Frontal Areas 11 and 13 Spared Monkeys' Performance on the Object Discrimination Reversal Task J. Neurosci., March 4, 2009; 29(9): 2794 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. VOLZ, R. RUBSAMEN, and D. Y. VON CRAMON Cortical regions activated by the subjective sense of perceptual coherence of environmental sounds: A proposal for a neuroscience of intuition Cogn Affect Behav Neurosci, September 1, 2008; 8(3): 318 - 328. [Abstract] [PDF]
|
|
|
|
 |
|
 A. B. Hains and A. F.T. Arnsten Molecular mechanisms of stress-induced prefrontal cortical impairment: Implications for mental illness Learn. Mem., August 6, 2008; 15(8): 551 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. I. Buia and P. H. Tiesinga Role of Interneuron Diversity in the Cortical Microcircuit for Attention J Neurophysiol, May 1, 2008; 99(5): 2158 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Barbas and B. Zikopoulos The Prefrontal Cortex and Flexible Behavior Neuroscientist, October 1, 2007; 13(5): 532 - 545. [Abstract] [PDF]
|
|
|
|
 |
|
 M Medalla, P Lera, M Feinberg, and H Barbas Specificity in Inhibitory Systems Associated with Prefrontal Pathways to Temporal Cortex in Primates Cereb Cortex, September 1, 2007; 17(suppl_1): i136 - i150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chana, I. P. Everall, L. Crews, D. Langford, A. Adame, I. Grant, M. Cherner, D. Lazzaretto, R. Heaton, R. Ellis, et al. Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users Neurology, October 24, 2006; 67(8): 1486 - 1489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Miller and X.-J. Wang From the Cover: Inhibitory control by an integral feedback signal in prefrontal cortex: A model of discrimination between sequential stimuli PNAS, January 3, 2006; 103(1): 201 - 206. [Abstract] [Full Text] [PDF]
|
|