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Cerebral Cortex Advance Access published online on December 8, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh213
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© Oxford University Press 2004; all rights reserved

Article

A role of MAP1B in Reelin-dependent Neuronal Migration

Christian González-Billault 1, José A. Del Río 2, Jesús M. Ureña 3, Eva M. Jiménez-Mateos 4, María J. Barallobre 3, Marta Pascual 3, Lluís Pujadas 3, Sergi Simó 3, Anna La Torre 3, Rosalina Gavin 3, Francisco Wandosell 4, Eduardo Soriano 3, and Jesús Ávila 4*

1 Centro de Biología Molecular, Universidad Autonoma de Madrid-CSIC, Madrid 28049, Spain; Present address: Department of Biology and Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB), Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago, Chile
2 IRBB-Barcelona Science Park and Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain
3 IRBB-Barcelona Science Park and Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain
4 Centro de Biología Molecular, Universidad Autonoma de Madrid-CSIC, Madrid 28049, Spain

* To whom correspondence should be addressed.
Jesús Ávila, E-mail: javila{at}cbm.uam.es


  Abstract

The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.

Keywords: cyclin-dependent kinase 5; glycogen synthase kinase 3; microtubule-associated protein; neuronal migration; Reelin.
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