Skip Navigation



Cerebral Cortex Advance Access published online on September 30, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh188
© 2004 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/7/888    most recent
bhh188v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tsujimoto, S.
Right arrow Articles by Sawaguchi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsujimoto, S.
Right arrow Articles by Sawaguchi, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Article

Context-dependent Representation of Response-outcome in Monkey Prefrontal Neurons

Satoshi Tsujimoto 1 and Toshiyuki Sawaguchi 1*

1 Laboratory of Cognitive Neurobiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology, Saitama 332-0012, Japan

* To whom correspondence should be addressed. E-mail: toshi-sw{at}med.hokudai.ac.jp.


  Abstract

For behaviour to be purposeful, it is important to monitor the preceding behavioural context, particularly for factors regarding stimulus, response and outcome. The dorsolateral prefrontal cortex (DLPFC) appears to play a major role in such a context-dependent, flexible behavioural control system, and this area is likely to have a neuronal mechanism for such retrospective coding, which associates response-outcome with the information and/or neural systems that guided the response. To address this hypothesis, we recorded neuronal activity from the DLPFC of monkeys performing memory- and sensory-guided saccade tasks, each of which had two conditions with reward contingencies. We found that post-response activity of a subset of DLPFC neurons was modulated by three factors relating to earlier events: the direction of the immediately preceding response, its outcome (reward or non-reward) and the information type (memory or sensory) that guided the response. Such neuronal coding should play a role in associating response-outcome with information and/or neural systems used to guide behaviour -- that is, ‘retrospective monitoring’ of behavioural context and/or neural systems used for guiding behaviour -- thereby contributing to context-dependent, flexible control of behaviours.

Keywords: behavioural control; post-response activity; prefrontal cortex; primate; retrospective monitoring; single-neuron activity.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Tsujimoto, A. Genovesio, and S. P. Wise
Monkey Orbitofrontal Cortex Encodes Response Choices Near Feedback Time
J. Neurosci., February 25, 2009; 29(8): 2569 - 2574.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Tsujimoto, A. Genovesio, and S. P. Wise
Transient Neuronal Correlations Underlying Goal Selection and Maintenance in Prefrontal Cortex
Cereb Cortex, December 1, 2008; 18(12): 2748 - 2761.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. H. Donahue and H. Seo
Attaching Values to Actions: Action and Outcome Encoding in the Primate Caudate Nucleus
J. Neurosci., April 30, 2008; 28(18): 4579 - 4580.
[Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Genovesio, S. Tsujimoto, and S. P. Wise
Neuronal Activity Related to Elapsed Time in Prefrontal Cortex
J Neurophysiol, May 1, 2006; 95(5): 3281 - 3285.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.