Skip Navigation



Cerebral Cortex Advance Access published online on September 15, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh172
© 2004 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/6/708    most recent
bhh172v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Narr, K. L.
Right arrow Articles by Thompson, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Narr, K. L.
Right arrow Articles by Thompson, P. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Article

Mapping Cortical Thickness and Gray Matter Concentration in First Episode Schizophrenia

Katherine L. Narr 1, Robert M. Bilder 2, Arthur W. Toga 3*, Roger P. Woods 4, David E. Rex 1, Philip R. Szeszko 4, Delbert Robinson 4, Serge Sevy 4, Handan Gunduz-Bruce 4, Yung-Ping Wang 1, Heather DeLuca 1, and Paul M. Thompson 1

1 Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA
2 Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA
3 Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA
4 Department of Psychiatry Research, The Zucker Hillside Hospital, North-Shore Long Island Jewish Health Systems, Glen Oaks, NY, USA

* To whom correspondence should be addressed. E-mail: toga{at}loni.ucla.edu.


  Abstract

We mapped regional changes in cortical thickness and intensity-based cortical gray matter concentration in first episode schizophrenia. High-resolution magnetic resonance images were obtained from 72 (51 male, 21 female) first episode patients and 78 (37 male, 41 female) healthy subjects similar in age. Cortical pattern matching methods allowed comparisons of cortical thickness and gray matter concentration at thousands of homologous cortical locations between subjects in three dimensions. Principal components analyses reduced measures obtained across the cortex to identify global differences in cortical thickness/gray matter concentration. First principal component factor scores showed significant effects of diagnosis, sex and age for both cortical measures. Diagnosis and age effects remained significant after brain size correction. Cortical thickness and gray matter concentration values were highly correlated. Statistical maps showed significant regional gray matter thinning in frontal, temporal and parietal heteromodal association cortices bilaterally in first episode patients. Regional reductions in cortical gray matter concentration were similar but pronounced in the superior temporal lobe. Regional reductions in cortical thickness and gray matter concentration are present at disease onset in brain regions linked with functional disturbances in schizophrenia. Cortical thickness and gray matter concentration mapping produce similar results, although the concentration metric may be influenced by diagnostic differences in extra-cortical cerebrospinal fluid and surface curvature/complexity.

Keywords: brain structure; heteromodal association cortices; imaging; prefrontal cortices; superior temporal gyrus.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
E. Luders, C. Gaser, K. L. Narr, and A. W. Toga
Why Sex Matters: Brain Size Independent Differences in Gray Matter Distributions between Men and Women
J. Neurosci., November 11, 2009; 29(45): 14265 - 14270.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
X. Wang, M. Gerken, M. Dennis, R. Mooney, J. Kane, S. Khuder, H. Xie, W. Bauer, A. V. Apkarian, and J. Wall
Profiles of Precentral and Postcentral Cortical Mean Thicknesses in Individual Subjects over Acute and Subacute Time-Scales
Cereb Cortex, October 13, 2009; (2009) bhp226v1.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
A. L. Goldman, L. Pezawas, V. S. Mattay, B. Fischl, B. A. Verchinski, Q. Chen, D. R. Weinberger, and A. Meyer-Lindenberg
Widespread Reductions of Cortical Thickness in Schizophrenia and Spectrum Disorders and Evidence of Heritability
Arch Gen Psychiatry, May 1, 2009; 66(5): 467 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. S. Peterson, V. Warner, R. Bansal, H. Zhu, X. Hao, J. Liu, K. Durkin, P. B. Adams, P. Wickramaratne, and M. M. Weissman
Cortical thinning in persons at increased familial risk for major depression
PNAS, April 14, 2009; 106(15): 6273 - 6278.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. E. Bearden, T. G.M. van Erp, R. A. Dutton, A. D. Lee, T. J. Simon, T. D. Cannon, B. S. Emanuel, D. McDonald-McGinn, E. H. Zackai, and P. M. Thompson
Alterations in Midline Cortical Thickness and Gyrification Patterns Mapped in Children with 22q11.2 Deletions
Cereb Cortex, January 1, 2009; 19(1): 115 - 126.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Haller, S. J. Borgwardt, C. Schindler, J. Aston, E. W. Radue, and A. Riecher-Rossler
Can Cortical Thickness Asymmetry Analysis Contribute to Detection of At-Risk Mental State and First-Episode Psychosis?: A Pilot Study
Radiology, January 1, 2009; 250(1): 212 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer, A. Y. Deutch, G. E. Duncan, C. E. Marx, J. R. Aprille, D. S. Dwyer, X.-M. Li, S. P. Mahadik, et al.
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Pharmacol. Rev., September 1, 2008; 60(3): 358 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. Luders, K. L. Narr, R. M. Bilder, P. R. Szeszko, M. N. Gurbani, L. Hamilton, A. W. Toga, and C. Gaser
Mapping the Relationship between Cortical Convolution and Intelligence: Effects of Gender
Cereb Cortex, September 1, 2008; 18(9): 2019 - 2026.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
P. C.M. Wong, C. M. Warrier, V. B. Penhune, A. K. Roy, A. Sadehh, T. B. Parrish, and R. J. Zatorre
Volume of Left Heschl's Gyrus and Linguistic Pitch Learning
Cereb Cortex, April 1, 2008; 18(4): 828 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Soc Cogn Affect NeurosciHome page
B. K. Holzel, U. Ott, T. Gard, H. Hempel, M. Weygandt, K. Morgen, and D. Vaitl
Investigation of mindfulness meditation practitioners with voxel-based morphometry
Soc Cogn Affect Neurosci, March 1, 2008; 3(1): 55 - 61.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
N. Gogtay
Cortical Brain Development in Schizophrenia: Insights From Neuroimaging Studies in Childhood-Onset Schizophrenia
Schizophr Bull, January 1, 2008; 34(1): 30 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. R. Sowell, S. N. Mattson, E. Kan, P. M. Thompson, E. P. Riley, and A. W. Toga
Abnormal Cortical Thickness and Brain Behavior Correlation Patterns in Individuals with Heavy Prenatal Alcohol Exposure
Cereb Cortex, January 1, 2008; 18(1): 136 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
P M THOMPSON and L G APOSTOLOVA
Computational anatomical methods as applied to ageing and dementia
Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S78 - S91.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
Y. He, Z. J. Chen, and A. C. Evans
Small-World Anatomical Networks in the Human Brain Revealed by Cortical Thickness from MRI
Cereb Cortex, October 1, 2007; 17(10): 2407 - 2419.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
V. M. Narayan, K. L. Narr, V. Kumari, R. P. Woods, P. M. Thompson, A. W. Toga, and T. Sharma
Regional Cortical Thinning in Subjects With Violent Antisocial Personality Disorder or Schizophrenia
Am J Psychiatry, September 1, 2007; 164(9): 1418 - 1427.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. J. Lin, N. Salamon, A. D. Lee, R. A. Dutton, J. A. Geaga, K. M. Hayashi, E. Luders, A. W. Toga, J. Engel Jr, and P. M. Thompson
Reduced Neocortical Thickness and Complexity Mapped in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Cereb Cortex, September 1, 2007; 17(9): 2007 - 2018.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. L. Narr, R. P. Woods, P. M. Thompson, P. Szeszko, D. Robinson, T. Dimtcheva, M. Gurbani, A. W. Toga, and R. M. Bilder
Relationships between IQ and Regional Cortical Gray Matter Thickness in Healthy Adults
Cereb Cortex, September 1, 2007; 17(9): 2163 - 2171.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
N. Gogtay, D. Greenstein, M. Lenane, L. Clasen, W. Sharp, P. Gochman, P. Butler, A. Evans, and J. Rapoport
Cortical Brain Development in Nonpsychotic Siblings of Patients With Childhood-Onset Schizophrenia
Arch Gen Psychiatry, July 1, 2007; 64(7): 772 - 780.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. R. Sowell, B. S. Peterson, E. Kan, R. P. Woods, J. Yoshii, R. Bansal, D. Xu, H. Zhu, P. M. Thompson, and A. W. Toga
Sex Differences in Cortical Thickness Mapped in 176 Healthy Individuals between 7 and 87 Years of Age
Cereb Cortex, July 1, 2007; 17(7): 1550 - 1560.
[Abstract] [Full Text] [PDF]

Home page
 J Am Acad Psychiatry LawHome page
S. K. Erickson, J. R. Ciccone, S. B. Schwarzkopf, J. S. Lamberti, and M. J. Vitacco
Legal Fallacies of Antipsychotic Drugs
J Am Acad Psychiatry Law, June 1, 2007; 35(2): 235 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
V. M. Goghari, K. Rehm, C. S. Carter, and A. W. MacDonald III
Regionally Specific Cortical Thinning and Gray Matter Abnormalities in the Healthy Relatives of Schizophrenia Patients
Cereb Cortex, February 1, 2007; 17(2): 415 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
C. Pantelis, M. Yucel, S. J Wood, D. Velakoulis, D. Sun, G. Berger, G. W Stuart, A. Yung, L. Phillips, and P. D McGorry
Structural Brain Imaging Evidence for Multiple Pathological Processes at Different Stages of Brain Development in Schizophrenia
Schizophr Bull, July 1, 2005; 31(3): 672 - 696.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.