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Cerebral Cortex Advance Access published online on July 21, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh137
© 2004 by Oxford University Press
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Article

Neonatal NMDA Receptor Blockade Disturbs Neuronal Migration in Rat Somatosensory Cortex In Vivo

Petra Reiprich 1, Werner Kilb 2, Heiko J. Luhmann 2*

1 Institute for Medicine, Research Center Jülich, Jülich, Germany
2 Institute of Physiology and Pathophysiology, University of Mainz, Mainz, Germany

* To whom correspondence should be addressed. E-mail: luhmann{at}uni-mainz.de.


  Abstract

Glutamate plays an important role in the control of neuronal migration in the developing cerebral cortex. The present study describes changes in the structure and function of the cerebral cortex after transient blockade of N-methyl-D-aspartate (NMDA) receptors during the late period of neuronal migration. Elvax slices containing the NMDA antagonist MK801 were placed over the somatosensory cortex of newborn rats and the drug was released over a period of 2-3 days. After survival times of 1 or 2 weeks, neuroanatomical and in vitro electrophysiological analyses revealed prominent structural and functional alterations in the cortical region underlying the implant. Cortical lamination was disturbed and heterotopic cell clusters were found in layer I of MK801-treated animals. Morphologically identified pyramidal neurons recorded in MK801-treated cortex revealed late NMDA receptor-mediated synaptic inputs and fragile monosynaptic responses at stimulation frequencies >0.2 Hz. Our data indicate that impairment of NMDA receptors during early corticogenesis induces neuronal migration disorders and delays the functional maturation of the developing cortical network.

Keywords: heterotopia; maturation; neonatal; pyramidal neurons; synaptic responses.
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