Skip Navigation



Cerebral Cortex Advance Access published online on July 6, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh121
© 2004 by Oxford University Press
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
15/2/187    most recent
bhh121v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Suzuki, M.
Right arrow Articles by Kurachi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, M.
Right arrow Articles by Kurachi, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Article

Male-specific Volume Expansion of the Human Hippocampus during Adolescence

Michio Suzuki 1*, Hirofumi Hagino 1, Shigeru Nohara 1, Shi-Yu Zhou 1, Yasuhiro Kawasaki 1, Tsutomu Takahashi 1, Mie Matsui 2, Hikaru Seto 3, Taketoshi Ono 4, Masayoshi Kurachi 1

1 Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
2 Department of Psychology, Toyama Medical and Pharmaceutical University, Toyama, Japan
3 Department of Radiology, Toyama Medical and Pharmaceutical University, Toyama, Japan
4 Department of Physiology, Toyama Medical and Pharmaceutical University, Toyama, Japan

* To whom correspondence should be addressed. E-mail: suzukim{at}ms.toyama-mpu.ac.jp.


  Abstract

To clarify the developmental brain changes during adolescence, brain morphology was compared between healthy younger adolescent and elder adolescent subjects using both voxel-based morphometry (VBM) and volumetric region-of-interest (ROI) analysis of magnetic resonance imaging (MRI). High-resolution three-dimensional MRI scans were acquired in 23 (10 males and 13 females) younger adolescent subjects (13-14 years) and 30 (15 males and 15 females) elder adolescent subjects (19-21 years). Whole-brain analysis by VBM revealed that the elder adolescent subjects had significantly more gray matter in the left medial temporal regions than the younger adolescent subjects and significantly less gray matter in the left medial frontal region (Brodmann area 6). In the volumetric analysis, significantly less cerebral gray matter volume and significantly greater cerebral white matter volume were found in elder adolescents compared with younger adolescents. The volume of the hippocampus was significantly larger in male elder adolescents than in male younger adolescents. The volume of the parahippocampal gyrus did not differ between younger and elder adolescent subjects. These results suggest a robust maturational process ongoing in the human hippocampus during adolescence, especially in males. The possible relevance of these findings to progress in myelination and implications in psychiatric disorders were discussed.

Keywords: developmental change; gender difference; MRI; myelination.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
P. Dazzan, K. D. Morgan, X. Chitnis, J. Suckling, C. Morgan, P. Fearon, P. K. McGuire, P. B. Jones, J. Leff, and R. M. Murray
The Structural Brain Correlates of Neurological Soft Signs in Healthy Individuals
Cereb Cortex, August 1, 2006; 16(8): 1225 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. D. Romeo, R. Bellani, I. N. Karatsoreos, N. Chhua, M. Vernov, C. D. Conrad, and B. S. McEwen
Stress History and Pubertal Development Interact to Shape Hypothalamic-Pituitary-Adrenal Axis Plasticity
Endocrinology, April 1, 2006; 147(4): 1664 - 1674.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Suzuki, S.-Y. Zhou, T. Takahashi, H. Hagino, Y. Kawasaki, L. Niu, M. Matsui, H. Seto, and M. Kurachi
Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis
Brain, September 1, 2005; 128(9): 2109 - 2122.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.