Cerebral Cortex Advance Access published online on June 24, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh112
© 2004 by Oxford University Press
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Speciation Mechanisms 1, National Institute for Basic Biology, Aichi 444-8585, Japan
* To whom correspondence should be addressed. E-mail: yamamori{at}nibb.ac.jp.
The neocortex consists of histochemically, connectionally, and functionally distinguishable areas. Recently, molecular biological techniques have enabled us to find rare types of genes expressed in specific neocortical areas. We previously reported occ1 gene as preferentially expressed in the primary visual cortex (V1), using the differential display method. Here, by differential display, we found selective and strong expression of the serum retinol-binding protein (RBP) gene, in higher-order association areas. In V1, RBP mRNA was expressed only in the superficial part of layer II, but its expression increased, involving deeper layers, along the visual pathway. In visual association areas such as TE, RBP mRNA was strongly expressed in both supra- and infragranular layers. In primary auditory and somatosensory areas, as in V1, RBP expression was low, and restricted to the upper part of the supragranular layers. The laminar pattern of RBP expression is in marked contrast with that of occ1; and in early visual areas where both genes are expressed, these occur in distinct sublayers within the supragranular layers. In neonatal monkeys, the area-specific expression pattern of RBP was less distinct, suggesting that the characteristic expression of RBP in higher-order association areas is mainly established postnatally.
Article
Retinol-binding Protein Gene is Highly Expressed in Higher-order Association Areas of the Primate Neocortex
2 Laboratory for Neural Architecture, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan
3 Division of Speciation Mechanisms 1, National Institute for Basic Biology, Aichi 444-8585, Japan; Present address: The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Takaji, Y. Komatsu, A. Watakabe, T. Hashikawa, and T. Yamamori Paraneoplastic Antigen-Like 5 Gene (PNMA5) Is Preferentially Expressed in the Association Areas in a Primate Specific Manner Cereb Cortex, December 1, 2009; 19(12): 2865 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watakabe, Y. Komatsu, O. Sadakane, S. Shimegi, T. Takahata, N. Higo, S. Tochitani, T. Hashikawa, T. Naito, H. Osaki, et al. Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses Cereb Cortex, August 1, 2009; 19(8): 1915 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahata, Y. Komatsu, A. Watakabe, T. Hashikawa, S. Tochitani, and T. Yamamori Differential Expression Patterns of occ1-Related Genes in Adult Monkey Visual Cortex Cereb Cortex, August 1, 2009; 19(8): 1937 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watakabe, N. Ichinohe, S. Ohsawa, T. Hashikawa, Y. Komatsu, K. S. Rockland, and T. Yamamori Comparative Analysis of Layer-Specific Genes in Mammalian Neocortex Cereb Cortex, August 1, 2007; 17(8): 1918 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahata, Y. Komatsu, A. Watakabe, T. Hashikawa, S. Tochitani, and T. Yamamori Activity-dependent Expression of occ1 in Excitatory Neurons Is a Characteristic Feature of the Primate Visual Cortex Cereb Cortex, July 1, 2006; 16(7): 929 - 940. [Abstract] [Full Text] [PDF]
|
|