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Cerebral Cortex Advance Access published online on April 27, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh073
© 2004 by Oxford University Press
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Article

Cell Type- and Region-specific Expression of Neurogranin mRNA in the Cerebral Cortex of the Macaque Monkey

Noriyuki Higo 1*, Takao Oishi 2, Akiko Yamashita 3, Keiji Matsuda 1, Motoharu Hayashi 4

1 Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Umezono, Tsukuba, 305-8568, Japan
2 Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Umezono, Tsukuba, 305-8568, Japan; Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi 484-8506, Japan
3 Division of Applied System Neuroscience, Advanced Medical Science Course, Nihon University School of Medicine, Oyaguchi-Kamimachi, Itabashi, Tokyo 173-8610, Japan
4 Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi 484-8506, Japan

* To whom correspondence should be addressed. E-mail: n.higo{at}aist.go.jp.


  Abstract

Neurogranin is a postsynaptic substrate for protein kinase C (PKC). It has been identified in the central nervous system, and the expression has been related to postsynaptic plasticity. Using non-radioactive in situ hybridization histochemistry, we investigated whether mRNA expression of neurogranin varied among the cerebral region and cell types. In most areas of the neocortex excluding area OC (the primary visual area), intense signals were observed in the pyramidal cells in layers III, V and VI. In area OC, intense signals were observed in layers IV as well as layers III and VI. We previously showed that intense signals for GAP-43, a presynaptic PKC substrate, were observed in relay neurons of the lateral geniculate nucleus. From this result and the present result in area OC, we conclude that both pre- and postsynaptic PKC substrates (GAP-43 and neurogranin) are abundant in the geniculocortical synapses. In the hippocampus, intense signals were observed in the pyramidal cells in the subiculum. Taken together with our previous study showing intense signals for GAP-43 in Ammon's horn, the result indicates that both PKC substrates are abundant in the connections between neurons in Ammon's horn and in the subiculum.

Key Words: GAP-43, plasticity, primate, protein kinase C, RC3


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