Cerebral Cortex Advance Access published online on March 28, 2004
Cerebral Cortex, doi:10.1093/cercor/bhh011
© 2004 by Oxford University Press
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1 Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA; Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA
* To whom correspondence should be addressed. E-mail: ys11{at}columbia.edu.
The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation. Key Words:
cognitive function, covariance analysis, functional imaging, neural networks, non-verbal recognition memory, sleep deprivation
Article
Identification and Differential Vulnerability of a Neural Network in Sleep Deprivation
2 Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA
3 Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA; Departments of Neurology and Psychology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA
4 Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA; Department of Neurology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA
5 Department of Radiology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA
6 Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA
7 Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA; Departments of Neurology, Psychiatry and Psychology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA
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