Cerebral Cortex, Vol. 9, No. 8, 815-823,
December 1999
© 1999 Oxford University Press
The Functional Neuroanatomy of Target Detection: An fMRI Study of Visual and Auditory Oddball Tasks
1 Max-Planck-Institut für Hirnforschung, Frankfurt am Main, , 2 Department of Psychiatry, Division of Clinical Neurophysiology, , 3 Department of Neurology and , 4 Department of Neuroradiology, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany and , 5 Department of Psychiatry, University of Bern, Switzerland
Address correspondence to Dr David E.J. Linden, Department of Psychiatry I, Division of Clinical Neurophysiology, Heinrich-Hoffmann-Straße 10, DE-60528 Frankfurt am Main, Germany. Email: linden{at}mpih-frankfurt.mpg.de.
The neuronal response patterns that are required for an adequate behavioural reaction to subjectively relevant changes in the environment are commonly studied by means of oddball paradigms, in which occasional ‘target’ stimuli have to be detected in a train of frequent ‘non-target’ stimuli. The detection of such task-relevant stimuli is accompanied by a parietocentral positive component of the event-related potential, the P300. We performed EEG recordings of visual and auditory event-related potentials and functional magnetic resonance imaging (fMRI) when healthy subjects performed an oddball task. Significant increases in fMRI signal for target versus non-target conditions were observed in the supramarginal gyrus, frontal operculum and insular cortex bilaterally, and in further circumscribed parietal and frontal regions. These effects were consistent over various stimulation and response modalities and can be regarded as specific for target detection in both the auditory and the visual modality. These results therefore contribute to the understanding of the target detection network in human cerebral cortex and impose constraints on attempts at localizing the neuronal P300 generator. This is of importance both from a neurobiological perspective and because of the widespread application of the physiological correlates of target detection in clinical P300 studies.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J.-R. Duann, J. S. Ide, X. Luo, and C.-s. R. Li Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition J. Neurosci., August 12, 2009; 29(32): 10171 - 10179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Eagleman and V. Pariyadath Is subjective duration a signature of coding efficiency? Phil Trans R Soc B, July 12, 2009; 364(1525): 1841 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Christ, D. C. Van Essen, J. M. Watson, L. E. Brubaker, and K. B. McDermott The Contributions of Prefrontal Cortex and Executive Control to Deception: Evidence from Activation Likelihood Estimate Meta-analyses Cereb Cortex, July 1, 2009; 19(7): 1557 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Hutchinson, M. R. Uncapher, and A. D. Wagner Posterior parietal cortex and episodic retrieval: Convergent and divergent effects of attention and memory Learn. Mem., May 23, 2009; 16(6): 343 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Walker, T. W. Robbins, and A. C. Roberts Response Disengagement on a Spatial Self-Ordered Sequencing Task: Effects of Regionally Selective Excitotoxic Lesions and Serotonin Depletion within the Prefrontal Cortex J. Neurosci., May 6, 2009; 29(18): 6033 - 6041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Reynolds, R. West, and T. Braver Distinct Neural Circuits Support Transient and Sustained Processes in Prospective Memory and Working Memory Cereb Cortex, May 1, 2009; 19(5): 1208 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gamer, O. Klimecki, T. Bauermann, P. Stoeter, and G. Vossel fMRI-activation patterns in the detection of concealed information rely on memory-related effects Soc Cogn Affect Neurosci, March 3, 2009; (2009) nsp005v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hampshire, R. Thompson, J. Duncan, and A. M. Owen Selective tuning of the right inferior frontal gyrus during target detection Cogn Affect Behav Neurosci, March 1, 2009; 9(1): 103 - 112. [Abstract] [PDF]
|
|
|
|
|
|
C. Alain, K. L. McDonald, N. Kovacevic, and A. R. McIntosh Spatiotemporal Analysis of Auditory 'What' and 'Where' Working Memory Cereb Cortex, February 1, 2009; 19(2): 305 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gomot, M. K. Belmonte, E. T. Bullmore, F. A. Bernard, and S. Baron-Cohen Brain hyper-reactivity to auditory novel targets in children with high-functioning autism Brain, September 1, 2008; 131(9): 2479 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Stevens, G. D. Pearlson, and K. A. Kiehl An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder Am J Psychiatry, November 1, 2007; 164(11): 1737 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Shulman, S. V. Astafiev, M. P. McAvoy, G. d'Avossa, and M. Corbetta Right TPJ Deactivation during Visual Search: Functional Significance and Support for a Filter Hypothesis Cereb Cortex, November 1, 2007; 17(11): 2625 - 2633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Plailly, B. Tillmann, and J.-P. Royet The Feeling of Familiarity of Music and Odors: The Same Neural Signature? Cereb Cortex, November 1, 2007; 17(11): 2650 - 2658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Demiralp, C. S. Herrmann, M. E. Erdal, T. Ergenoglu, Y. H. Keskin, M. Ergen, and H. Beydagi DRD4 and DAT1 Polymorphisms Modulate Human Gamma Band Responses Cereb Cortex, May 1, 2007; 17(5): 1007 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tamm, V. Menon, and A. L. Reiss Parietal Attentional System Aberrations During Target Detection in Adolescents With Attention Deficit Hyperactivity Disorder: Event-Related fMRI Evidence Am J Psychiatry, June 1, 2006; 163(6): 1033 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bledowski, K. C. Kadosh, M. Wibral, B. Rahm, R. A. Bittner, K. Hoechstetter, M. Scherg, K. Maurer, R. Goebel, and D. E. J. Linden Mental Chronometry of Working Memory Retrieval: A Combined Functional Magnetic Resonance Imaging and Event-Related Potentials Approach J. Neurosci., January 18, 2006; 26(3): 821 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Eichele, K. Specht, M. Moosmann, M. L. A. Jongsma, R. Q. Quiroga, H. Nordby, and K. Hugdahl Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI PNAS, December 6, 2005; 102(49): 17798 - 17803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. J. Linden The P300: Where in the Brain Is It Produced and What Does It Tell Us? Neuroscientist, December 1, 2005; 11(6): 563 - 576. [Abstract] [PDF]
|
|
|
|
|
|
P. V. Peers, C. J.H. Ludwig, C. Rorden, R. Cusack, C. Bonfiglioli, C. Bundesen, J. Driver, N. Antoun, and J. Duncan Attentional Functions of Parietal and Frontal Cortex Cereb Cortex, October 1, 2005; 15(10): 1469 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Kincade, R. A. Abrams, S. V. Astafiev, G. L. Shulman, and M. Corbetta An Event-Related Functional Magnetic Resonance Imaging Study of Voluntary and Stimulus-Driven Orienting of Attention J. Neurosci., May 4, 2005; 25(18): 4593 - 4604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bledowski, D. Prvulovic, K. Hoechstetter, M. Scherg, M. Wibral, R. Goebel, and D. E. J. Linden Localizing P300 Generators in Visual Target and Distractor Processing: A Combined Event-Related Potential and Functional Magnetic Resonance Imaging Study J. Neurosci., October 20, 2004; 24(42): 9353 - 9360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pollmann, J. Lepsien, K. Hugdahl, and D. Y. von Cramon Auditory Target Detection in Dichotic Listening Involves the Orbitofrontal and Hippocampal Paralimbic Belts Cereb Cortex, August 1, 2004; 14(8): 903 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ford, M. Gray, S. L. Whitfield, A. U. Turken, G. Glover, W. O. Faustman, and D. H. Mathalon Acquiring and Inhibiting Prepotent Responses in Schizophrenia: Event-Related Brain Potentials and Functional Magnetic Resonance Imaging Arch Gen Psychiatry, February 1, 2004; 61(2): 119 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Shulman, M. P. McAvoy, M. C. Cowan, S. V. Astafiev, A. P. Tansy, G. d'Avossa, and M. Corbetta Quantitative Analysis of Attention and Detection Signals During Visual Search J Neurophysiol, November 1, 2003; 90(5): 3384 - 3397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Blankenburg, J. Ruben, R. Meyer, J. Schwiemann, and A. Villringer Evidence for a Rostral-to-Caudal Somatotopic Organization in Human Primary Somatosensory Cortex with Mirror-reversal in Areas 3b and 1 Cereb Cortex, September 1, 2003; 13(9): 987 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M R Piras, I Magnano, E D G Canu, K S Paulus, W M Satta, A Soddu, M Conti, A Achene, G Solinas, and I Aiello Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings J. Neurol. Neurosurg. Psychiatry, July 1, 2003; 74(7): 878 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pompeia, G. M. Manzano, J. C. F. Galduroz, S. Tufik, and O. F. A. Bueno Lorazepam induces an atypical dissociation of visual and auditory event-related potentials J Psychopharmacol, January 1, 2003; 17(1): 31 - 40. [Abstract] [PDF]
|
|
|
|
|
|
G. L. Shulman, A. P. Tansy, M. Kincade, S. E. Petersen, M. P. McAvoy, and M. Corbetta Reactivation of Networks Involved in Preparatory States Cereb Cortex, June 1, 2002; 12(6): 590 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Downar, A. P. Crawley, D. J. Mikulis, and K. D. Davis A Cortical Network Sensitive to Stimulus Salience in a Neutral Behavioral Context Across Multiple Sensory Modalities J Neurophysiol, January 1, 2002; 87(1): 615 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Braver, D. M. Barch, J. R. Gray, D. L. Molfese, and A. Snyder Anterior Cingulate Cortex and Response Conflict: Effects of Frequency, Inhibition and Errors Cereb Cortex, September 1, 2001; 11(9): 825 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ruben, J. Schwiemann, M. Deuchert, R. Meyer, T. Krause, G. Curio, K. Villringer, R. Kurth, and A. Villringer Somatotopic Organization of Human Secondary Somatosensory Cortex Cereb Cortex, May 1, 2001; 11(5): 463 - 473. [Abstract] [Full Text] [PDF]
|
|