Cerebral Cortex, Vol 8, 261-268, Copyright © 1998 by Oxford University Press
CE Young, K Arima, J Xie, L Hu, TG Beach, P Falkai and WG Honer
Regional abnormalities of brain connectivity may be an important substrate
for the expression of schizophrenia, a severe form of mental illness. Brain
imaging and postmortem morphometric studies indicate hippocampal structure
is abnormal in schizophrenia. To study molecular components of hippocampal
connectivity the presynaptic proteins SNAP-25 and synaptophysin were
assayed in postmortem samples. Immunocytochemical studies indicated reduced
SNAP-25 immunoreactivity in schizophrenia compared to controls,
particularly in the terminal fields of entorhinal cortex projections.
Although there were no overall changes in synaptophysin immunoreactivity,
in the granule cell layer of the dentate gyrus synaptophysin
immunoreactivity was increased in schizophrenia. These results indicate
that disconnection of a subset of hippocampal circuitry from the entorhinal
cortex, as well as intrinsic changes in hippocampal connectivity, may
contribute to the mechanism of illness in schizophrenia.
ARTICLES
SNAP-25 deficit and hippocampal connectivity in schizophrenia
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
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