Cerebral Cortex Advance Access originally published online on April 8, 2009
Cerebral Cortex 2009 19(Supplement 1):i107-i113; doi:10.1093/cercor/bhp044
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This article appears in the following Cerebral Cortex issue: Cortical Development: Neural Stem Cells to Neural Circuits Chania, Greece, May 22-25, 2008 [View the issue table of contents]
Transcriptional Control of Neuronal Migration in the Developing Mouse Brain
1 Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas, and Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain, 2 PhD Program in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
Address correspondence to email: o.marin{at}umh.es.
The molecular mechanisms controlling neuronal migration have many similarities with those described for axon guidance. For instance, migrating neurons and growing axons are instructed toward their final destination by the same guidance molecules and are able to adapt their response to those cues by modulating the expression of guidance receptors. Transcriptional regulation is thought to be a key determinant in this later process, although we are just beginning to identify the contribution of these mechanisms in neuronal migration. In this review, we will describe recent progress made in understanding the contribution of transcription factors in controlling neuronal migration in the developing mouse brain, with a special focus on the developing telencephalon.
Key Words: guidance interneuron neuronal migration telencephalon transcription factor