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Cerebral Cortex Advance Access originally published online on June 26, 2006
Cerebral Cortex 2007 17(5):1160-1163; doi:10.1093/cercor/bhl026
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Additive Effects of Serotonin Transporter and Tryptophan Hydroxylase-2 Gene Variation on Emotional Processing

Martin J. Herrmann1,2, Theresa Huter1, Frauke Müller1, Andreas Mühlberger2, Paul Pauli2, Andreas Reif1, Tobias Renner1, Turhan Canli3,4, Andreas J. Fallgatter1 and Klaus-Peter Lesch1

1 Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany, 2 Department of Psychology, University of Würzburg, Würzburg, Germany, 3 Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA, 4 Department of Psychology, Stony Brook University, Stony Brook, NY, USA

Address correspondence to Martin Herrmann, PhD, Genomic Imaging, Department of Psychiatry and Psychotherapy, Fuechsleinstr 15, 97080 Wuerzburg, Germany. Email: Herrmann_M{at}klinik.uni-wuerzburg.de.

Prior studies reported that functional variants of both the serotonin transporter (5-HTT) and tryptophan hydroxylase-2 genes (TPH2), 2 key regulators of the serotonergic signaling pathway, modulate amygdala activation during emotional processing. We addressed the question whether these 2 gene variants modulate each other, using an emotional picture-processing task. Specifically, we measured event-related potentials (ERPs) during a passive emotional picture perception task, focusing on ERPs for the early posterior negativity (EPN) around 240 ms and for the slow wave starting at 315 ms. We found evidence for increased neural activity at 240 ms in individuals who carried 1 or 2 copies of the low-expression short variant of the 5-HTT. Carriers of T variant of the TPH2 also showed a tendency toward increased neural activity at 240 ms. Moreover, we observed an additive effect of both genotypes for EPN, with highest neural activity to emotional stimuli in individuals carrying combination of both short variant of 5-HTT and T variant of TPH2. Our results indicate that both the 5-HTT and the TPH2 genotypes modulate the sensory encoding of affective stimuli during early steps of visual processing and reveal additive effects of 2 genes in the serotonergic control of emotion regulation.

Key Words: emotion • ERP • genetics • 5-HTT • TPH2


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