Cerebral Cortex Advance Access originally published online on April 7, 2006
Cerebral Cortex 2007 17(3):562-574; doi:10.1093/cercor/bhj181
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Cytoarchitectonic Analysis of the Human Extrastriate Cortex in the Region of V5/MT+: A Probabilistic, Stereotaxic Map of Area hOc5
1 C. and O. Vogt Institute for Brain Research, Heinrich Heine University, D-40225 Düsseldorf, Germany, 2 Institute of Medicine, Research Center Jülich, D-52425 Jülich, Germany, 3 Institute of Anatomy, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia, 4 Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany, 5 Brain Imaging Center West, Jülich, Germany
Address correspondence email: k.amunts{at}fz-juelich.de.
Functional imaging studies identified a motion-sensitive area (V5/MT+) in the vicinity of the posterior branch of the inferior temporal sulcus that has no correlate in any classical cytoarchitectonic map. The aim of the present study was to identify a cytoarchitectonic correlate of this region in 10 human postmortem brains and to provide a probability map of this area. Observer-independent mapping revealed an area, hOc5 (h for human, Oc for occipital lobe), that has a broad layer III, a high cell density in layer II/III, and a low one in layer V. Most of area hOc5 is found in the depths of the anterior occipital sulcus and the anterior parts of either the inferior lateral occipital or the inferior occipital sulcus. After 3-dimensional reconstruction and registration to a standard reference space, a probability map of the area measured the individual variability of its size and location. The mean spatial locations of area hOc5 are –43, –73, 10 (left) and 49, –70, 11 (right). The locations and their relationships to sulci strongly suggest that hOc5 is the cytoarchitectonic correlate of human V5/MT+. This hypothesis was supported by comparing the cytoarchitectonic probabilistic map with results from a functional imaging study.
Key Words: cortex • cytoarchitecture • human visual cortex • probabilistic maps • V5/MT+
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