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Cerebral Cortex Advance Access originally published online on March 31, 2006
Cerebral Cortex 2007 17(2):475-491; doi:10.1093/cercor/bhj164
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org.

The Ferret Auditory Cortex: Descending Projections to the Inferior Colliculus

Victoria M. Bajo, Fernando R. Nodal, Jennifer K. Bizley, David R. Moore1 and Andrew J. King

Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK, 1 Current address: Medical Research Council Institute of Hearing Research, University Park, Nottingham NG7 1BD, UK

Address correspondence to Dr Victoria M. Bajo, Department of Physiology, Anatomy, and Genetics, Sherrington Building, Oxford University, Parks Road, Oxford OX1 3PT, UK. Email: Victoria.bajo{at}physiol.ox.ac.uk.

Descending corticofugal projections are thought to play a critical role in shaping the responses of subcortical neurons. Here, we examine the origins and targets of ferret auditory corticocollicular projections. We show that the ectosylvian gyrus (EG), where the auditory cortex is located, can be subdivided into middle, anterior, and posterior regions according to the pattern of cytochrome oxidase staining and immunoreactivity for the neurofilament antibody SMI32. Injection of retrograde tracers in the inferior colliculus (IC) labeled large layer V pyramidal cells throughout the EG and adjacent sulci. Each region of the EG has a different pattern of descending projections. Neurons in the primary auditory fields in the middle EG project to the lateral nucleus (LN) of the ipsilateral IC and bilaterally to the dorsal cortex and dorsal part of the central nucleus (CN). The projection to these dorsomedial regions of the IC is predominantly ipsilateral and topographically organized. The secondary cortical fields in the posterior EG target the same midbrain areas but exclude the CN of the IC. A smaller projection to the ipsilateral LN also arises from the anterior EG, which is the only region of auditory cortex to target tegmental areas surrounding the IC, including the superior colliculus, periaqueductal gray, intercollicular tegmentum, and cuneiform nucleus. This pattern of corticocollicular connectivity is consistent with regional differences in physiological properties and provides another basis for subdividing ferret auditory cortex into functionally distinct areas.

Key Words: anterograde labeling • ectosylvian gyrus • hearing • layer V pyramidal cells • midbrain • retrograde labeling


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