Skip Navigation


Cerebral Cortex Advance Access originally published online on February 8, 2006
Cerebral Cortex 2007 17(1):81-91; doi:10.1093/cercor/bhj126
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
17/1/81    most recent
bhj126v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Dumitriu, D.
Right arrow Articles by Yuste, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dumitriu, D.
Right arrow Articles by Yuste, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Correlation Between Axonal Morphologies and Synaptic Input Kinetics of Interneurons from Mouse Visual Cortex

Daniella Dumitriu1, Rosa Cossart1,3, Josh Huang2 and Rafael Yuste1

1 Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY 10027, USA, 2 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA, 3 Current address: Institut de Neurobiologie de la Mediterranée, Institut National de la Santé et de la Recherche Médicale, U29, 13673 Marseille, France

Address correspondence to Rafael Yuste, Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, Box 2435, New York, NY 10027, USA. rmy5{at}columbia.edu.

Neocortical interneurons display great morphological and physiological variability and are ideally positioned to control circuit dynamics, although their exact role is still poorly understood. To better understand this diversity, we have performed a detailed anatomical and physiological characterization of 3 subtypes of visual cortex interneurons, isolated from transgenic mice which express green fluorescent protein in somatostatin, parvalbumin, and neuropeptide Y positive neurons. We find that these 3 groups of interneurons have systematic differences in dendritic and axonal morphologies and also characteristically differ in the frequencies, amplitude, and kinetics of the spontaneous excitatory and inhibitory synaptic currents they receive. Moreover, we detect a correlation between the kinetics of their synaptic inputs and quantitative aspects of their axonal arborizations. This suggests that different interneuron types could channel different temporal patterns of activity. Our results also confirm the importance of the axonal morphology to classify interneurons.

Key Words: cortex • EPSP • GABA • GFP • IPSP


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
I. Vardya, K. R. Drasbek, Z. Dosa, and K. Jensen
Cell Type-Specific GABAA Receptor-Mediated Tonic Inhibition in Mouse Neocortex
J Neurophysiol, July 1, 2008; 100(1): 526 - 532.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M.C. Inda, J. DeFelipe, and A. Munoz
Morphology and Distribution of Chandelier Cell Axon Terminals in the Mouse Cerebral Cortex and Claustroamygdaloid Complex
Cereb Cortex, April 24, 2008; (2008) bhn057v1.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.