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Cerebral Cortex 2006 16(Supplement 1):i82-i88; doi:10.1093/cercor/bhk003
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Cellular Patterns of Transcription Factor Expression in Developing Cortical Interneurons

Inma Cobos, Jason E. Long, Myo T. Thwin and John L. Rubenstein

Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158, USA

Address correspondence to John L. Rubenstein, Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, Genetics, Development and Behavioral Sciences Building, 2nd Floor South, Room Rock Hall 284C, 1550 4th Street, University of California—San Francisco, San Francisco, CA 94158-2611, USA. Email: john.rubenstein{at}ucsf.edu.

Most {gamma}-aminobutyric acidergic interneurons in the neocortex and hippocampus are derived from subpallial progenitors in the medial ganglionic eminence and migrate tangentially to the pallium, where they differentiate into a diverse set of neuronal subtypes. Toward elucidating the mechanisms underlying the generation of interneuron diversity, we have studied in mice the expression patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 bZIP (MafB). Their patterns of expression change during interneuron differentiation and show distinct distributions within interneuron subpopulations in adult neocortex. This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes.

Key Words: calretinin • GAD • inhibition • parvalbumin • somatostatin


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