Skip Navigation

Cerebral Cortex 2006 16(Supplement 1):i26-i34; doi:10.1093/cercor/bhk011
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lukaszewicz, A.
Right arrow Articles by Dehay, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lukaszewicz, A.
Right arrow Articles by Dehay, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The Concerted Modulation of Proliferation and Migration Contributes to the Specification of the Cytoarchitecture and Dimensions of Cortical Areas

Agnès Lukaszewicz1,2,6, Véronique Cortay1,2, Pascale Giroud1,2, Michel Berland1,2,3, Iain Smart4, Henry Kennedy1,2 and Colette Dehay1,2,5

1 Institut National de la Santé et de la Recherche Médicale U371, Cerveau et Vision, Department of Stem Cell and Cortical Development, 69500 Bron, France, 2 Université Claude Bernard Lyon I, Institut Fédératif de Recherche 19, 69500 Bron, France, 3 Hôpital Lyon Sud, 69495 Pierre-Bénite, France, 4 Department of Anatomy and Physiology, School of Life Sciences, Old Medical School, The University, Dundee DD1 4HN, Scotland and 5 PrimaStem, 69500 Bron, France, 6 Current address: Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA

Address correspondence to Colette Dehay, Department of Stem Cell and Cortical Development, INSERM, U371, Cerveau et Vision, 18 avenue du Doyen Lépine, 69500 Bron, France. Email: dehay{at}lyon.inserm.fr.

Regionalization of cell cycle kinetics of cortical precursors has been described in nonhuman primates and rodents indicating a fate map of areas as distinct proliferative programs in the germinal zones of the neocortex. It remains to be understood how proliferative gradients during corticogenesis are transcribed into a stepwise function to form adult areal borders. Here we have used the monkey areas 17 and 18, which show striking cytoarchitectonic differences, as a model system for studying how developmental events establish areal boundaries in the adult. We present data indicating that the events that are involved in the formation of a sharp border separating 2 areas involve an orchestration of diverse phenomena including differential rates of proliferation, migration, and tangential expansion.

Key Words: cortical plate • neocortex • primate • subventricular zone


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.