Cerebral Cortex Advance Access originally published online on September 14, 2005
Cerebral Cortex 2006 16(7):949-959; doi:10.1093/cercor/bhj037
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Evidence for Separate Perceptual Reactivation and Search Processes during Remembering
1 Department of Radiology, Washington University, St Louis, MO 63110, USA, 2 Department of Neurology, Washington University, St Louis, MO 63110, USA, 3 Department of Psychology, Washington University, St Louis, MO 63110, USA, 4 Department of Anatomy & Neurobiology, Washington University, St Louis, MO 63110, USA and 5 Howard Hughes Medical Institute, Washington University, St Louis, MO 63110, USA
Address correspondence to Mark E. Wheeler, University of Pittsburgh, 608 Learning Research and Development Center, 3939 O'Hara Street, Pittsburgh, PA 15260, USA. Email: wheelerm{at}pitt.edu.
Remembering involves the coordinated recruitment of strategic search processes and processes involved in reconstructing the content of the past experience. In the present study we used a cueing paradigm based on event-related functional magnetic resonance imaging to separate activity in the initial preparation phases of retrieval from later phases during which retrieval search ensued, and detailed auditory and visual memories were reconstructed. Results suggest a dissociation among inferior temporal (IT) and parieto-occipital (PO) processing regions in how they were influenced by preparatory cues prior to remembering, and indicate a dissociation in how they were influenced by the subsequent validity of those cues during remembering. Regions in IT cortex appeared to show search-related activity during retrieval, as well as robust modality effects, but they were not influenced by preparatory cues. These findings suggest a specific role for IT regions in reconstruction of visual details during remembering. While dorsal regions in parietal and superior occipital cortex also appeared to show search-related activity as well as robust modality effects, they were also influenced by preparatory cues during the retrieval phase, and to a lesser degree during the cue phase. These findings indicate a role in integrating perceptual reactivation and search processes during remembering.
Key Words: attention • cueing • episodic memory • parieto-occipital • remembering • retrieval
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