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Cerebral Cortex Advance Access originally published online on January 18, 2006
Cerebral Cortex 2006 16(12):1759-1765; doi:10.1093/cercor/bhj114
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Ventromedial Prefrontal Cortex Is Obligatory for Consolidation and Reconsolidation of Object Recognition Memory

Irit Akirav1,2 and Mouna Maroun2

1 Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, 2 The Brain and Behavior Research Center, Department of Neurobiology and Ethology, Faculty of Science and Science Education, University of Haifa, Haifa 31905, Israel

Address correspondence to Mouna Maroun, PhD, The Brain and Behavior Center, Faculty of Science and Science Education, University of Haifa, Haifa 31905, Israel. Email: mmaroun{at}psy.haifa.ac.il.

Once consolidated, a long-term memory item could regain susceptibility to consolidation blockers, that is, reconsolidate, upon its reactivation. Both consolidation and reconsolidation require protein synthesis, but it is not yet known how similar these processes are in terms of molecular, cellular, and neural circuit mechanisms. Whereas most previous studies focused on aversive conditioning in the amygdala and the hippocampus, here we examine the role of the ventromedial prefrontal cortex (vmPFC) in consolidation and reconsolidation of object recognition memory. Object recognition memory is the ability to discriminate the familiarity of previously encountered objects. We found that microinfusion of the protein synthesis inhibitor anisomycin or the N-methyl-D-aspartate (NMDA) receptor antagonist D,L-2-amino-5-phosphonovaleric acid (APV) into the vmPFC, immediately after training, resulted in impairment of long-term (24 h) but not short-term (3 h) recognition memory. Similarly, microinfusion of anisomycin or APV into the vmPFC immediately after reactivation of the long-term memory impaired recognition memory 24 h, but not 3 h, post-reactivation. These results indicate that both protein synthesis and NMDA receptors are required for consolidation and reconsolidation of recognition memory in the vmPFC.

Key Words: anisomycin • consolidation • NMDA • object recognition memory • reconsolidation • ventromedial prefrontal cortex


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