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Cerebral Cortex Advance Access originally published online on November 24, 2004
Cerebral Cortex 2005 15(7):1075-1087; doi:10.1093/cercor/bhh208
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Cerebral Cortex V 15 N 7 © Oxford University Press 2004; all rights reserved

Disturbing Visual Working Memory: Electrophysiological Evidence for a Role of the Prefrontal Cortex in Recovery from Interference

Klaus Kessler1 and Markus Kiefer2

1 Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany and 2 Department of Psychiatry, University of Ulm, Ulm, Germany

Address correspondence to Dr Klaus Kessler, University of Düsseldorf, Neurology, MEG Lab, Moorenstr. 5, Düsseldorf 40225, Germany. Email: klaus.kessler{at}med.uni-duesseldorf.de.

Single cell recordings in monkeys support the notion that the lateral prefrontal cortex (PFC) controls reactivation of visual working memory representations when rehearsal is disrupted. In contrast, recent fMRI findings yielded a double dissociation for PFC and the medial temporal lobe (MTL) in a letter working memory task. PFC was engaged in interference protection during reactivation while MTL was prominently involved in the retrieval of the letter representations. We present event-related potential data (ERP) that support PFC involvement in the top-down control of reactivation during a visual working memory task with endogenously triggered recovery after visual interference. A differentiating view is proposed for the role of PFC in working memory with respect to endogenous/exogenous control and to stimulus type. General implications for binding and retention mechanisms are discussed.

Key Words: Binding • ERP • medial temporal lobe • memory reactivation • occipito-temporal cortex • retention


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